-transparent.png){kind=logo}
A new cell line from a sporadic Wilms' tumor was established and extensively characterized. In nude mice, the tumor cells rapidly formed tumors which, in histological characteristics and extracellular-matrix (ECM) composition resembled sarcomatoid Wilms' tumor. The tumor cells produced B chains of laminin, but no A chain, and laminin was deposited into the ECM in a punctate pattern typical of sarcomatoid tumors. Strong expression of tenascin was detected within the stromal ECM of the tumors. Species-specific antibodies reacting either with human or with mouse tenascin showed that tenascin was exclusively derived from mouse host cells. The human Wilms' cell line thus induced a strong stromal response with increased deposition of tenascin. The cell line may be useful for studying the behavior of sarcomatoid Wilms' tumor cells and for identifying factors that stimulate synthesis of tenascin.
J F Talts, and
E Aufderheide, and
L Sorokin, and
G Ocklind, and
R Mattsson, and
P Ekblom
January 1994,
Medical oncology (Northwood, London, England),
J F Talts, and
E Aufderheide, and
L Sorokin, and
G Ocklind, and
R Mattsson, and
P Ekblom
January 1988,
Pediatric pathology,
J F Talts, and
E Aufderheide, and
L Sorokin, and
G Ocklind, and
R Mattsson, and
P Ekblom
October 1998,
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie,
J F Talts, and
E Aufderheide, and
L Sorokin, and
G Ocklind, and
R Mattsson, and
P Ekblom
September 1985,
Zhonghua zhong liu za zhi [Chinese journal of oncology],
J F Talts, and
E Aufderheide, and
L Sorokin, and
G Ocklind, and
R Mattsson, and
P Ekblom
October 2010,
Zhonghua bing li xue za zhi = Chinese journal of pathology,
J F Talts, and
E Aufderheide, and
L Sorokin, and
G Ocklind, and
R Mattsson, and
P Ekblom
January 1990,
Acta histochemica. Supplementband,
J F Talts, and
E Aufderheide, and
L Sorokin, and
G Ocklind, and
R Mattsson, and
P Ekblom
April 1977,
Journal of the National Cancer Institute,
J F Talts, and
E Aufderheide, and
L Sorokin, and
G Ocklind, and
R Mattsson, and
P Ekblom
October 1979,
In vitro,
J F Talts, and
E Aufderheide, and
L Sorokin, and
G Ocklind, and
R Mattsson, and
P Ekblom
May 1990,
Carcinogenesis,
J F Talts, and
E Aufderheide, and
L Sorokin, and
G Ocklind, and
R Mattsson, and
P Ekblom
January 1988,
International journal of cancer,
