Combined external beam and low dose rate intraluminal radiotherapy in oesophageal cancer. 1993

R J Caspers, and A H Zwinderman, and G Griffioen, and K Welvaart, and E N Sewsingh, and J Davelaar, and J W Leer
Department of Radiotherapy, University Hospital Leiden, The Netherlands.

Thirty-five patients with oesophageal cancer were treated with external beam irradiation (50-60 Gy) followed by a boost-dose of 15-20 Gy by means of low dose rate intraluminal brachytherapy. Of the 35 patients treated 17 (48%) were pretreated with laser therapy or dilation alone. Although the intraluminal application time was long (up to 36 h) the treatment was feasible with minor acute toxicity. The palliative effect of the combined treatment was excellent; a 6 weeks post-treatment 32 of the 35 patients were able to eat solid food. Late complications were seen in six patients (17%), of which only one was severe and probably treatment-related. The median survival was 11 months; the 1- and 2-year survival were 42% and 10% respectively. The survival was strongly dependent on local control. Distant metastases became evident in 23% of patients. The interval between external radiotherapy and brachytherapy seemed to be critical. The results were compared with 68 historical controls. A significantly better survival was observed at 6 months. It is concluded that low dose rate intraluminal brachytherapy is a useful and feasible technique to increase the total dose for obtaining a better local control. The shortcomings are discussed and ideas for further improvement are mentioned.

UI MeSH Term Description Entries
D007496 Iridium Radioisotopes Unstable isotopes of iridium that decay or disintegrate emitting radiation. Ir atoms with atomic weights 182-190, 192, and 194-198 are radioactive iridium isotopes. Radioisotopes, Iridium
D008297 Male Males
D008722 Methods A series of steps taken in order to conduct research. Techniques,Methodological Studies,Methodological Study,Procedures,Studies, Methodological,Study, Methodological,Method,Procedure,Technique
D009364 Neoplasm Recurrence, Local The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site. Local Neoplasm Recurrence,Local Neoplasm Recurrences,Locoregional Neoplasm Recurrence,Neoplasm Recurrence, Locoregional,Neoplasm Recurrences, Local,Recurrence, Local Neoplasm,Recurrence, Locoregional Neoplasm,Recurrences, Local Neoplasm,Locoregional Neoplasm Recurrences,Neoplasm Recurrences, Locoregional,Recurrences, Locoregional Neoplasm
D010166 Palliative Care Care alleviating symptoms without curing the underlying disease. (Stedman, 25th ed) Palliative Treatment,Palliative Supportive Care,Palliative Surgery,Palliative Therapy,Surgery, Palliative,Therapy, Palliative,Care, Palliative,Palliative Treatments,Supportive Care, Palliative,Treatment, Palliative,Treatments, Palliative
D011832 Radiation Injuries Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES. Radiation Sickness,Radiation Syndrome,Injuries, Radiation,Injury, Radiation,Radiation Injury,Radiation Sicknesses,Radiation Syndromes,Sickness, Radiation,Sicknesses, Radiation,Syndrome, Radiation,Syndromes, Radiation
D011879 Radiotherapy Dosage The total amount of radiation absorbed by tissues as a result of radiotherapy. Dosage, Radiotherapy,Dosages, Radiotherapy,Radiotherapy Dosages
D012074 Remission Induction Therapeutic act or process that initiates a response to a complete or partial remission level. Induction of Remission,Induction, Remission,Inductions, Remission,Remission Inductions
D001918 Brachytherapy A collective term for interstitial, intracavity, and surface radiotherapy. It uses small sealed or partly-sealed sources that may be placed on or near the body surface or within a natural body cavity or implanted directly into the tissues. Curietherapy,Implant Radiotherapy,Plaque Therapy, Radioisotope,Radioisotope Brachytherapy,Radiotherapy, Interstitial,Radiotherapy, Intracavity,Radiotherapy, Surface,Brachytherapy, Radioisotope,Interstitial Radiotherapy,Intracavity Radiotherapy,Radioisotope Plaque Therapy,Radiotherapy, Implant,Surface Radiotherapy,Therapy, Radioisotope Plaque
D003680 Deglutition Disorders Difficulty in SWALLOWING which may result from neuromuscular disorder or mechanical obstruction. Dysphagia is classified into two distinct types: oropharyngeal dysphagia due to malfunction of the PHARYNX and UPPER ESOPHAGEAL SPHINCTER; and esophageal dysphagia due to malfunction of the ESOPHAGUS. Dysphagia,Swallowing Disorders,Esophageal Dysphagia,Oropharyngeal Dysphagia,Deglutition Disorder,Disorders, Deglutition,Dysphagia, Esophageal,Dysphagia, Oropharyngeal,Swallowing Disorder

Related Publications

R J Caspers, and A H Zwinderman, and G Griffioen, and K Welvaart, and E N Sewsingh, and J Davelaar, and J W Leer
June 1993, Panminerva medica,
R J Caspers, and A H Zwinderman, and G Griffioen, and K Welvaart, and E N Sewsingh, and J Davelaar, and J W Leer
July 1994, International journal of radiation oncology, biology, physics,
R J Caspers, and A H Zwinderman, and G Griffioen, and K Welvaart, and E N Sewsingh, and J Davelaar, and J W Leer
July 2002, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
R J Caspers, and A H Zwinderman, and G Griffioen, and K Welvaart, and E N Sewsingh, and J Davelaar, and J W Leer
December 2003, International journal of radiation oncology, biology, physics,
R J Caspers, and A H Zwinderman, and G Griffioen, and K Welvaart, and E N Sewsingh, and J Davelaar, and J W Leer
March 1996, International journal of radiation oncology, biology, physics,
R J Caspers, and A H Zwinderman, and G Griffioen, and K Welvaart, and E N Sewsingh, and J Davelaar, and J W Leer
March 2021, Scientific reports,
R J Caspers, and A H Zwinderman, and G Griffioen, and K Welvaart, and E N Sewsingh, and J Davelaar, and J W Leer
July 1992, Clinical oncology (Royal College of Radiologists (Great Britain)),
R J Caspers, and A H Zwinderman, and G Griffioen, and K Welvaart, and E N Sewsingh, and J Davelaar, and J W Leer
June 2000, International journal of radiation oncology, biology, physics,
R J Caspers, and A H Zwinderman, and G Griffioen, and K Welvaart, and E N Sewsingh, and J Davelaar, and J W Leer
November 2003, Journal of the College of Physicians and Surgeons--Pakistan : JCPSP,
R J Caspers, and A H Zwinderman, and G Griffioen, and K Welvaart, and E N Sewsingh, and J Davelaar, and J W Leer
August 2018, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
Copied contents to your clipboard!