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BACKGROUND Many patients with non-Hodgkin's lymphomas are not cured by current therapies, and new approaches to treatment are needed. As part of an ongoing phase 1 study, we examined the effect of radioimmunotherapy with 131I-labeled B-cell-specific anti-CD20 monoclonal antibody in 10 patients with CD20-positive B-cell lymphomas in whom primary chemotherapy had failed. RESULTS Anti-B1 (anti-CD20) mouse monoclonal antibody trace-labeled with 131I (15 mg containing 5 mCi) was given intravenously at approximately one-week intervals: first, without pretreatment with unlabeled anti-B1 antibody, to all 10 patients; then, with pretreatment with 135 mg of unlabeled antibody, to 8 patients; and then, with pretreatment with 685 mg, to 2 patients. Serial quantitative gamma-camera images and measures of whole-body radioactivity were obtained after each tracer dose. All known disease sites larger than 2 cm could be imaged. The effect of a pretreatment dose of unlabeled anti-B1 antibody on targeting of the tumor with the radiolabeled antibody was variable. The pretreatment dose of unlabeled antibody that produced the highest ratio of the tumor dose to the whole-body dose in tracer studies was then used to deliver higher doses of radioactivity for radioimmunotherapy in nine patients. Three patients received doses designed to deliver 25 cGy to the whole body (two patients treated twice, six to eight weeks apart), four patients received 35 cGy (one patient treated twice), and two patients received 45 cGy (one patient treated twice); each dose contained 34 to 66 mCi of activity. Six of the nine treated patients had tumor responses, including patients with bulky or chemotherapy-resistant disease: four patients had complete remissions, and two had partial responses. Three patients had objective responses to tracer infusions before they received radioimmunotherapeutic doses. Of the four patients with complete remissions, one remained in remission for eight months and the other three continue to have no disease progression (for 11, 9, and 8 months). There was mild or no myelosuppression. CONCLUSIONS Radioimmunotherapy with [131I]anti-B1 antibody is a promising new treatment for lymphoma.
M S Kaminski, and
K R Zasadny, and
I R Francis, and
A W Milik, and
C W Ross, and
S D Moon, and
S M Crawford, and
J M Burgess, and
N A Petry, and
G M Butchko
March 2006,
Clinical and experimental medicine,
M S Kaminski, and
K R Zasadny, and
I R Francis, and
A W Milik, and
C W Ross, and
S D Moon, and
S M Crawford, and
J M Burgess, and
N A Petry, and
G M Butchko
March 2009,
Nihon Hoshasen Gijutsu Gakkai zasshi,
M S Kaminski, and
K R Zasadny, and
I R Francis, and
A W Milik, and
C W Ross, and
S D Moon, and
S M Crawford, and
J M Burgess, and
N A Petry, and
G M Butchko
August 1995,
Lancet (London, England),
M S Kaminski, and
K R Zasadny, and
I R Francis, and
A W Milik, and
C W Ross, and
S D Moon, and
S M Crawford, and
J M Burgess, and
N A Petry, and
G M Butchko
March 2002,
Journal of the American Academy of Dermatology,
M S Kaminski, and
K R Zasadny, and
I R Francis, and
A W Milik, and
C W Ross, and
S D Moon, and
S M Crawford, and
J M Burgess, and
N A Petry, and
G M Butchko
December 1986,
Cancer research,
M S Kaminski, and
K R Zasadny, and
I R Francis, and
A W Milik, and
C W Ross, and
S D Moon, and
S M Crawford, and
J M Burgess, and
N A Petry, and
G M Butchko
January 2002,
Nihon rinsho. Japanese journal of clinical medicine,
M S Kaminski, and
K R Zasadny, and
I R Francis, and
A W Milik, and
C W Ross, and
S D Moon, and
S M Crawford, and
J M Burgess, and
N A Petry, and
G M Butchko
April 2007,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
M S Kaminski, and
K R Zasadny, and
I R Francis, and
A W Milik, and
C W Ross, and
S D Moon, and
S M Crawford, and
J M Burgess, and
N A Petry, and
G M Butchko
January 2009,
Nuklearmedizin. Nuclear medicine,
M S Kaminski, and
K R Zasadny, and
I R Francis, and
A W Milik, and
C W Ross, and
S D Moon, and
S M Crawford, and
J M Burgess, and
N A Petry, and
G M Butchko
May 2003,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
M S Kaminski, and
K R Zasadny, and
I R Francis, and
A W Milik, and
C W Ross, and
S D Moon, and
S M Crawford, and
J M Burgess, and
N A Petry, and
G M Butchko
October 1999,
Clinical cancer research : an official journal of the American Association for Cancer Research,
