-transparent.png){kind=logo}
The supplementation with beta-carotene and canthaxanthin, two carotenoids with and without pro-vitamin A activity, reduced in vitro the number of micronuclei induced in human cultured lymphocytes by the chemotherapeutic radiomimetic drug bleomycin. The genotoxic activity of this substance is supposed to be mediated by a free radical mechanism. The reduction of micronucleated cells was in correlation with donors' carotenoid blood levels. It has been observed that 20 weeks are needed, following the end of carotenoid supplementation, in order to return to the high levels of micronuclei induced by bleomycin. It is suggested that this protective effect is due to the antioxidant properties of carotenoids acting against free radical-mediated genotoxic damage.
L Bianchi, and
F Tateo, and
R Pizzala, and
L A Stivala, and
M Grazia Verri, and
R Melli, and
L Santamaria
April 2018,
Drug and chemical toxicology,
L Bianchi, and
F Tateo, and
R Pizzala, and
L A Stivala, and
M Grazia Verri, and
R Melli, and
L Santamaria
November 1989,
Mutation research,
L Bianchi, and
F Tateo, and
R Pizzala, and
L A Stivala, and
M Grazia Verri, and
R Melli, and
L Santamaria
January 1983,
Hereditas,
L Bianchi, and
F Tateo, and
R Pizzala, and
L A Stivala, and
M Grazia Verri, and
R Melli, and
L Santamaria
January 2010,
Drug and chemical toxicology,
L Bianchi, and
F Tateo, and
R Pizzala, and
L A Stivala, and
M Grazia Verri, and
R Melli, and
L Santamaria
June 1990,
Jinrui idengaku zasshi. The Japanese journal of human genetics,
L Bianchi, and
F Tateo, and
R Pizzala, and
L A Stivala, and
M Grazia Verri, and
R Melli, and
L Santamaria
May 1994,
Mutation research,
L Bianchi, and
F Tateo, and
R Pizzala, and
L A Stivala, and
M Grazia Verri, and
R Melli, and
L Santamaria
March 2002,
Toxicology and applied pharmacology,
L Bianchi, and
F Tateo, and
R Pizzala, and
L A Stivala, and
M Grazia Verri, and
R Melli, and
L Santamaria
August 1982,
Mutation research,
L Bianchi, and
F Tateo, and
R Pizzala, and
L A Stivala, and
M Grazia Verri, and
R Melli, and
L Santamaria
January 2016,
Drug and chemical toxicology,
L Bianchi, and
F Tateo, and
R Pizzala, and
L A Stivala, and
M Grazia Verri, and
R Melli, and
L Santamaria
July 1996,
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
