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In this study we determined the occurrence of anti-neutrophil cytoplasmic antibodies (ANCA) and the specificity of these antibodies (Ab) in the serum of patients with Felty's syndrome (FS) and in serum of patients with uncomplicated rheumatoid arthritis (RA). ANCA, detected by indirect immunofluorescence on ethanol-fixed neutrophils, was found in 77% of 30 patients with FS and in 36% of 50 RA patients. Ab against lactoferrin (LF) occurred more frequently in FS patients (50%) than in RA patients (4%), whereas reactivity against the other cytoplasmic antigens tested (proteinase-3, myeloperoxidase and elastase) did not differ significantly between these patient groups. The specific reactivity of FS sera with LF was established by demonstrating that the Ab reactivity resided in IgG, was located in the F(ab')2 fragments and could be inhibited from binding to the ELISA plate-bound LF by purified LF in the fluid phase. These results demonstrate that anti-LF Ab occur in FS and suggest that the detection of anti-LF Ab in patients with FS may be useful in the diagnosis of FS.
I E Coremans, and
E C Hagen, and
E A van der Voort, and
F J van der Woude, and
M R Daha, and
F C Breedveld
February 1991,
Arthritis and rheumatism,
I E Coremans, and
E C Hagen, and
E A van der Voort, and
F J van der Woude, and
M R Daha, and
F C Breedveld
April 2012,
Arthritis and rheumatism,
I E Coremans, and
E C Hagen, and
E A van der Voort, and
F J van der Woude, and
M R Daha, and
F C Breedveld
November 1980,
The American journal of medicine,
I E Coremans, and
E C Hagen, and
E A van der Voort, and
F J van der Woude, and
M R Daha, and
F C Breedveld
November 2001,
The American journal of medicine,
I E Coremans, and
E C Hagen, and
E A van der Voort, and
F J van der Woude, and
M R Daha, and
F C Breedveld
November 1988,
The New England journal of medicine,
I E Coremans, and
E C Hagen, and
E A van der Voort, and
F J van der Woude, and
M R Daha, and
F C Breedveld
August 1995,
Journal of clinical pathology,
I E Coremans, and
E C Hagen, and
E A van der Voort, and
F J van der Woude, and
M R Daha, and
F C Breedveld
March 1998,
British journal of rheumatology,
I E Coremans, and
E C Hagen, and
E A van der Voort, and
F J van der Woude, and
M R Daha, and
F C Breedveld
February 1989,
Lancet (London, England),
I E Coremans, and
E C Hagen, and
E A van der Voort, and
F J van der Woude, and
M R Daha, and
F C Breedveld
January 1988,
British journal of haematology,
I E Coremans, and
E C Hagen, and
E A van der Voort, and
F J van der Woude, and
M R Daha, and
F C Breedveld
January 1993,
Advances in experimental medicine and biology,
