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On the role of corticosteroid-binding globulin (CBG) in modulating activity of glucocorticoids: developmental patterns for CBG, corticosterone, and a-fetoprotein levels in the rat serum. 1993

A A Tinnikov
Laboratory of Physiological Genetics, Russian Academy of Sciences, Siberian Department, Novosibirsk.

The levels of corticosterone, corticosteroid-binding globulin (CBG), and a-fetoprotein (AFP) were measured in the serum of developing rats. It has been shown that the dramatic increase in CBG concentration and the decrease in AFP concentration of the same degree occur in males and females during the third postnatal week. The considerable rise in corticosterone level was observed only during 4th postnatal week. The data obtained in the study suggest that CBG may be responsible for the essential contribution to the developmental rise in glucocorticoid activity.

UI MeSH Term Description Entries
D008297 Male Males
D003345 Corticosterone An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
D005260 Female Females
D000367 Age Factors Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time. Age Reporting,Age Factor,Factor, Age,Factors, Age
D000509 alpha-Fetoproteins The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life. alpha-Fetoprotein,alpha Fetoprotein,alpha Fetoproteins
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000831 Animals, Newborn Refers to animals in the period of time just after birth. Animals, Neonatal,Animal, Neonatal,Animal, Newborn,Neonatal Animal,Neonatal Animals,Newborn Animal,Newborn Animals
D014156 Transcortin A serpin family member that binds to and transports GLUCOCORTICOIDS in the BLOOD. Corticosteroid-Binding Globulin,Serpin A6,Corticosteroid Binding Globulin
D017208 Rats, Wistar A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain. Wistar Rat,Rat, Wistar,Wistar Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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