Breast cancer patients with chest wall recurrence or patients with advanced breast cancer pose a difficult challenge to surgeons. Surgical ablation results in not only a large soft tissue defect that needs cover but often, in addition, a significant bony chest wall defect. The majority of these patients would have already received irradiation or chemotherapy or both. Thus, wound healing is significantly impaired. For these reasons, surgery was previously not attractive as an alternative in the palliation of these patients. Over a one-year period, seven breast cancer patients had chest wall resection. Six patients had recurrent tumours and one had advanced primary breast cancer. Two of these patients required only extensive resection of soft tissue of the anterior chest wall. The other five patients required, in addition, resection of the bony chest wall. Myocutaneous flaps were used to repair the surgical defects in six of these patients. Five were rectus abdominis myocutaneous flaps and one a pectoralis major myocutaneous flap. In one patient, a deltovertebral skin flap, which is an axial pattern skin flap was used. Primary wound healing was achieved in five of six patients (83%). One patient died immediately post-operatively, the cause of which is unknown. One of the rectus abdominis flap needed an exploration but was ultimately salvaged. This paper demonstrates the usefulness of the myocutaneous flap in enabling surgery to become a modality for palliation of patients with recurrent and advanced breast cancer.