-transparent.png){kind=logo}
Activated autoreactive T cells are potentially pathogenic and regulated by clonotypic networks. Experimental autoimmune diseases can be treated by inoculation with autoreactive T cells (T cell vaccination). In the present study, patients with multiple sclerosis were inoculated with irradiated myelin basic protein (MBP)-reactive T cells. T cell responses to the inoculates were induced to deplete circulating MBP-reactive T cells in the recipients. Regulatory T cell lines isolated from the recipients inhibited T cells used for vaccination. The cytotoxicity of the CD8+ T cell lines was restricted by major histocompatibility antigens. Thus, clonotypic interactions regulating autoreactive T cells in humans can be induced by T cell vaccination.
J Zhang, and
R Medaer, and
P Stinissen, and
D Hafler, and
J Raus
July 1995,
Annals of the New York Academy of Sciences,
J Zhang, and
R Medaer, and
P Stinissen, and
D Hafler, and
J Raus
December 1995,
Journal of immunology (Baltimore, Md. : 1950),
J Zhang, and
R Medaer, and
P Stinissen, and
D Hafler, and
J Raus
March 1998,
Journal of immunology (Baltimore, Md. : 1950),
J Zhang, and
R Medaer, and
P Stinissen, and
D Hafler, and
J Raus
May 1988,
Neurology,
J Zhang, and
R Medaer, and
P Stinissen, and
D Hafler, and
J Raus
July 1995,
Annals of the New York Academy of Sciences,
J Zhang, and
R Medaer, and
P Stinissen, and
D Hafler, and
J Raus
January 2000,
Journal of neuroimmunology,
J Zhang, and
R Medaer, and
P Stinissen, and
D Hafler, and
J Raus
July 1990,
Immunology,
J Zhang, and
R Medaer, and
P Stinissen, and
D Hafler, and
J Raus
January 1990,
Progress in clinical and biological research,
J Zhang, and
R Medaer, and
P Stinissen, and
D Hafler, and
J Raus
July 1981,
Nature,
J Zhang, and
R Medaer, and
P Stinissen, and
D Hafler, and
J Raus
August 1995,
Journal of autoimmunity,
