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Absorption of recombinant human granulocyte colony-stimulating factor (rhG-CSF) and blood leukocyte dynamics following intranasal administration in rabbits. 1993
Y Watanabe, and
Y Matsumoto, and
M Yamaguchi, and
R Kikuchi, and
K Takayama, and
H Nomura, and
K Maruyama, and
M Matsumoto
Department of Pharmaceutics, Showa College of Pharmaceutical Sciences, Tokyo, Japan.
Absorption of recombinant human granulocyte colony-stimulating factors (rhG-CSF) following intranasal administration of aqueous preparations containing rhG-CSF with or without dimethyl-beta-cyclodextrin was investigated. It was found that rhG-CSF was absorbed and the total leukocyte numbers in peripheral blood markedly increased after intranasal instillation of rhG-CSF solution (pH 4) without excipients. Simultaneously administered dimethyl-beta-cyclodextrin enhanced nasal absorption of rhG-CSF. Consequently, serum rhG-CSF concentrations and total leukocyte numbers were greatly increased.
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