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A retrospective study was carried out to ascertain the blood bank provision required to support a liver transplant programme and to assess the effect of intraoperative aprotinin on blood product requirements in liver transplant recipients with cirrhosis. Sixty patients with end-stage liver disease underwent 62 consecutive orthotopic liver transplants between October 1988 and January 1991. The total and intraoperative requirements of red cells, platelets and fresh frozen plasma (FFP) were analysed for three groups of liver transplant recipients, those without cirrhosis (n = 15), those with cirrhosis (n = 25) and those with cirrhosis who received intraoperative aprotinin (n = 20). Fifteen without cirrhosis had mean total requirements of 15 units of red cells, 18 units of platelets and 16 units of FFP. Twenty patients with cirrhosis who received intraoperative aprotinin had broadly similar requirements. However, blood product requirements for 25 patients with cirrhosis were significantly greater (46 units of red cells, 41 units of platelets, 43 units of FFP, excluding the seven patients with primary biliary cirrhosis). We conclude that a liver transplant programme can be supported by a teaching hospital blood bank. The use of intraoperative aprotinin significantly reduces blood product requirements.
O Smith, and
G Hazlehurst, and
B Brozovic, and
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A Burroughs, and
S Mallett, and
K Dawson, and
A Mehta
October 1990,
Lancet (London, England),
O Smith, and
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A Burroughs, and
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A Mehta
April 2003,
Pediatric transplantation,
O Smith, and
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June 1994,
Transfusion,
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January 2006,
Acta cirurgica brasileira,
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June 2011,
Transplantation,
O Smith, and
G Hazlehurst, and
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A Mehta
March 2008,
World journal of gastroenterology,
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May 1996,
The Annals of thoracic surgery,
O Smith, and
G Hazlehurst, and
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December 1994,
Transplantation proceedings,
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A Mehta
January 2002,
Anesthesiology,
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March 1999,
Anesthesia and analgesia,
