-transparent.png){kind=logo}
Three cDNA clones homologous to rat neuronal nicotinic receptors were identified in a human brain stem library by screening at low stringency with a mixture of rat alpha 5, beta 2 and beta 4 subunit probes. Positive clones were further analysed by hybridisation at higher stringency with individual rat nicotinic receptor probes. One positive clone was found to encode a protein that exhibited characteristic features of a member of the ligand-gated ion channel class of protein subunits, and showed 89% homology with a rat beta 3 neuronal nicotinic receptor subunit. Northern blots demonstrated the presence of a 1.7 kb transcript in RNA extracted from adult human Pons. This clone has therefore been designated the human beta 3 neuronal nicotinic receptor subunit.
J J Willoughby, and
N N Ninkina, and
M M Beech, and
D S Latchman, and
J N Wood
April 1990,
Neuroscience letters,
J J Willoughby, and
N N Ninkina, and
M M Beech, and
D S Latchman, and
J N Wood
March 1989,
Journal of neurochemistry,
J J Willoughby, and
N N Ninkina, and
M M Beech, and
D S Latchman, and
J N Wood
January 1997,
Receptors & channels,
J J Willoughby, and
N N Ninkina, and
M M Beech, and
D S Latchman, and
J N Wood
February 1993,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
J J Willoughby, and
N N Ninkina, and
M M Beech, and
D S Latchman, and
J N Wood
June 1993,
Annals of the New York Academy of Sciences,
J J Willoughby, and
N N Ninkina, and
M M Beech, and
D S Latchman, and
J N Wood
January 2020,
Frontiers in physiology,
J J Willoughby, and
N N Ninkina, and
M M Beech, and
D S Latchman, and
J N Wood
March 1991,
Nature,
J J Willoughby, and
N N Ninkina, and
M M Beech, and
D S Latchman, and
J N Wood
July 1990,
Nucleic acids research,
J J Willoughby, and
N N Ninkina, and
M M Beech, and
D S Latchman, and
J N Wood
January 1997,
Clinical genetics,
J J Willoughby, and
N N Ninkina, and
M M Beech, and
D S Latchman, and
J N Wood
January 1995,
Receptors & channels,
