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The effects of 5,7-dihydroxytryptamine (5,7-DHT) and p-chlorophenylalanine (PCPA) on neuronal morphology were investigated in Achatina fulica by backfilling the cerebrobuccal connective with nickel-lysine. Backfilling 21 days following injections of either 5,7-DHT or PCPA revealed supernumerary staining of fibers in different pathways of the cerebral and buccal ganglia and novel staining of somata in the cerebral ganglia. HPLC measurements confirm that drug treatments led to a 30-46% depletion of serotonin (5-HT) in the buccal ganglia. These results support the role suggested for 5-HT as a neuritogenic modulator and additionally advise caution in the use of pharmacological depletors in studies examining serotonergic function.
M W Baker, and
M M Vohra, and
R P Croll
February 2006,
Brain research,
M W Baker, and
M M Vohra, and
R P Croll
June 1978,
Annals of the New York Academy of Sciences,
M W Baker, and
M M Vohra, and
R P Croll
November 1978,
The Journal of pharmacy and pharmacology,
M W Baker, and
M M Vohra, and
R P Croll
October 1982,
Brain research,
M W Baker, and
M M Vohra, and
R P Croll
April 2001,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
M W Baker, and
M M Vohra, and
R P Croll
June 1978,
Annals of the New York Academy of Sciences,
M W Baker, and
M M Vohra, and
R P Croll
October 1996,
Cellular and molecular neurobiology,
M W Baker, and
M M Vohra, and
R P Croll
December 1983,
Japanese journal of pharmacology,
M W Baker, and
M M Vohra, and
R P Croll
September 1974,
British journal of pharmacology,
M W Baker, and
M M Vohra, and
R P Croll
January 1999,
Journal of biomedical science,
