Biomaterial Database

Afferent projections to the reticular thalamic nucleus from the globus pallidus and the substantia nigra in the rat. 1993

J A Gandia, and S De Las Heras, and M García, and J M Giménez-Amaya

Departamento de Traumatología y Cirugía Ortopédica, Hospital Ramón y Cajal, Madrid, Spain.

This study was designed to explore the thalamic output of the globus pallidus (GP) and the pars reticulata (SNR) of the substantia nigra (SN) upon the reticular thalamic nucleus (Rt) in the rat. Thus, 13 animals were deeply anesthetized and stereotaxically injected with horseradish peroxidase (HRP) conjugated with wheat germ agglutinin (HRP-WGA) mixed with HRP free in different portions of GP and SN. Next, we evaluated the anterograde terminal labeling in the rostral two-thirds of Rt. Confirmatory results were obtained in our case material about the entity of GP reticular projections, and some new data are presented here regarding the projections from GP and SNR upon Rt. Among them we emphasize the following for the rostral two-thirds of this thalamic nucleus: a) the projections from GP are more abundant than those arising from SNR; b) a dorsoventral topographical design appears to be clear in the organization of the afferent connections from GP to Rt; c) SNR projects more abundantly to the ventral sectors of Rt; and d) the central core of Rt is more innervated by GP than by SNR, which innervates Rt mainly in its peripheral portions. These results raise the possibility of multiple and differentiated assignments of the output nuclei of the basal ganglia upon the thalamus and its connectivity.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D005260	Female		Females
D005917	Globus Pallidus	The representation of the phylogenetically oldest part of the corpus striatum called the paleostriatum. It forms the smaller, more medial part of the lentiform nucleus.	Paleostriatum,Pallidum,Pallidums
D006735	Horseradish Peroxidase	An enzyme isolated from horseradish which is able to act as an antigen. It is frequently used as a histochemical tracer for light and electron microscopy. Its antigenicity has permitted its use as a combined antigen and marker in experimental immunology.	Alpha-Peroxidase,Ferrihorseradish Peroxidase,Horseradish Peroxidase II,Horseradish Peroxidase III,Alpha Peroxidase,II, Horseradish Peroxidase,III, Horseradish Peroxidase,Peroxidase II, Horseradish,Peroxidase III, Horseradish,Peroxidase, Ferrihorseradish,Peroxidase, Horseradish
D000344	Afferent Pathways	Nerve structures through which impulses are conducted from a peripheral part toward a nerve center.	Afferent Pathway,Pathway, Afferent,Pathways, Afferent
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001370	Axonal Transport	The directed transport of ORGANELLES and molecules along nerve cell AXONS. Transport can be anterograde (from the cell body) or retrograde (toward the cell body). (Alberts et al., Molecular Biology of the Cell, 3d ed, pG3)	Axoplasmic Flow,Axoplasmic Transport,Axoplasmic Streaming,Axonal Transports,Axoplasmic Flows,Axoplasmic Transports,Streaming, Axoplasmic,Transport, Axonal,Transport, Axoplasmic,Transports, Axonal,Transports, Axoplasmic
D013378	Substantia Nigra	The black substance in the ventral midbrain or the nucleus of cells containing the black substance. These cells produce DOPAMINE, an important neurotransmitter in regulation of the sensorimotor system and mood. The dark colored MELANIN is a by-product of dopamine synthesis.	Nigra, Substantia,Nigras, Substantia,Substantia Nigras
D013787	Thalamic Nuclei	Several groups of nuclei in the thalamus that serve as the major relay centers for sensory impulses in the brain.	Nuclei, Thalamic
D014909	Wheat Germ Agglutinins	Lectins purified from the germinating seeds of common wheat (Triticum vulgare); these bind to certain carbohydrate moieties on cell surface glycoproteins and are used to identify certain cell populations and inhibit or promote some immunological or physiological activities. There are at least two isoforms of this lectin.	Agglutinins, Wheat Germ,Lectins, Triticum Vulgare,Lectins, Wheat Germ,Triticum Vulgare Lectin,Triticum Vulgare Lectins,Wheat Germ Agglutinin,Wheat Germ Lectin,Wheat Germ Lectins,Wheat Germ Agglutinin Isolectin 1,Wheat Germ Agglutinin Isolectin 2,Agglutinin, Wheat Germ,Germ Agglutinin, Wheat,Germ Lectin, Wheat,Lectin, Triticum Vulgare,Lectin, Wheat Germ,Vulgare Lectin, Triticum