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To assess the relationship between hepatitis C virus (HCV) infection and essential mixed cryoglobulinaemia (EMC), sera from 23 patients with EMC were tested for IgG and IgM antibodies to HCV antigens and for HCV RNA. Quantitative HCV antibody studies were performed on serum and purified cryoglobulin fractions. HCV antibodies of both IgG and IgM class were found in 22 (96%) patients. Ten of these were also HCV-RNA positives. Higher titres of anti-HCV IgM were present in the 11 patients with evidence of liver damage. Anti-HCV IgG antibodies were shown to be concentrated in the IgG fraction of cryoglobulins in all eight patients studied. These results strongly suggest a role for HCV in the pathogenesis of EMC.
A L'Abbate, and
S Cutrupi, and
M Rognetta, and
C Fabiano, and
A Craxi
March 1992,
Clinical and experimental immunology,
A L'Abbate, and
S Cutrupi, and
M Rognetta, and
C Fabiano, and
A Craxi
January 1991,
Voprosy virusologii,
A L'Abbate, and
S Cutrupi, and
M Rognetta, and
C Fabiano, and
A Craxi
July 1966,
Clinical and experimental immunology,
A L'Abbate, and
S Cutrupi, and
M Rognetta, and
C Fabiano, and
A Craxi
March 1994,
British journal of rheumatology,
A L'Abbate, and
S Cutrupi, and
M Rognetta, and
C Fabiano, and
A Craxi
July 1993,
European journal of clinical investigation,
A L'Abbate, and
S Cutrupi, and
M Rognetta, and
C Fabiano, and
A Craxi
June 1994,
British journal of rheumatology,
A L'Abbate, and
S Cutrupi, and
M Rognetta, and
C Fabiano, and
A Craxi
November 1995,
QJM : monthly journal of the Association of Physicians,
A L'Abbate, and
S Cutrupi, and
M Rognetta, and
C Fabiano, and
A Craxi
November 1997,
European journal of gastroenterology & hepatology,
A L'Abbate, and
S Cutrupi, and
M Rognetta, and
C Fabiano, and
A Craxi
August 1993,
British journal of rheumatology,
A L'Abbate, and
S Cutrupi, and
M Rognetta, and
C Fabiano, and
A Craxi
January 1993,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
