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The white-spotting (Ws) locus of rats represents a 12-base deletion of the c-kit receptor tyrosine kinase. Homozygous Ws/Ws rats are deficient in melanocytes, mast cells, and erythrocytes. Although mice possessing two mutant alleles at the c-kit (W) locus, such as mice of W/Wv genotype, show severe anemia even in adult age, the anemia of Ws/Ws rats remarkably ameliorated with age. We investigated the mechanism of the age-dependent amelioration. Bone marrow cells of Ws/Ws rats did not form macroscopic colonies in the spleen of irradiated rats, and the concentration of burst-forming unit-erythroid in the marrow of Ws/Ws rats was comparable with that of +/+ rats. Therefore, the increase in morphologically identifiable erythroid precursors in the marrow of Ws/Ws rats was attributed to the increased concentration of colony-forming unit-erythroid (CFU-E). Furthermore, the increase in CFU-E appeared to result from the increased concentration of erythropoietin (EPO). Because injections of relatively low doses of EPO cured the slight anemia that remained in adult Ws/Ws rats, CFU-E and/or its immediate precursors of Ws/Ws rats appeared to be more sensitive to EPO than those of W/Wv mice, in which a huge dose of EPO was necessary to cure the anemia.
M Morimoto, and
T Kasugai, and
H Tei, and
T Jippo-Kanemoto, and
Y Kanakura, and
Y Kitamura
April 1993,
The American journal of pathology,
M Morimoto, and
T Kasugai, and
H Tei, and
T Jippo-Kanemoto, and
Y Kanakura, and
Y Kitamura
February 1994,
Blood,
M Morimoto, and
T Kasugai, and
H Tei, and
T Jippo-Kanemoto, and
Y Kanakura, and
Y Kitamura
October 1991,
Blood,
M Morimoto, and
T Kasugai, and
H Tei, and
T Jippo-Kanemoto, and
Y Kanakura, and
Y Kitamura
July 2003,
Journal of hepatology,
M Morimoto, and
T Kasugai, and
H Tei, and
T Jippo-Kanemoto, and
Y Kanakura, and
Y Kitamura
April 2008,
Cancer cell international,
M Morimoto, and
T Kasugai, and
H Tei, and
T Jippo-Kanemoto, and
Y Kanakura, and
Y Kitamura
July 1997,
Cell and tissue research,
M Morimoto, and
T Kasugai, and
H Tei, and
T Jippo-Kanemoto, and
Y Kanakura, and
Y Kitamura
August 2003,
Experimental cell research,
M Morimoto, and
T Kasugai, and
H Tei, and
T Jippo-Kanemoto, and
Y Kanakura, and
Y Kitamura
August 1995,
Gastroenterology,
M Morimoto, and
T Kasugai, and
H Tei, and
T Jippo-Kanemoto, and
Y Kanakura, and
Y Kitamura
November 1998,
Pathology international,
M Morimoto, and
T Kasugai, and
H Tei, and
T Jippo-Kanemoto, and
Y Kanakura, and
Y Kitamura
April 1988,
The EMBO journal,
