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Between January 1973 and February 1975, 77 adults with acute nonlymphoblastic leukemia were treated with a combination of daunorubicin, cytosine arabinoside, 6-thioguanine, prednisone, and vincristine in university-affiliated and private institutions. After 31 patients were treated (regimen 1) the doses of all drugs were significantly increased (regimen 2). Regimes 1 and 2 yielded CR rates of 59% (17 of 29 patients) and 70% (32 of 46 patients) respectively. With regimens 2 the mean number of courses and the median number of days to CR decreased from 3 to 1.4 and from 46 to 29 respectively. Failure to achieve CR was due to persistent leukemia during regimen 1 and fatal infections during regimen 2. With regimen 2 ten of 20 patients (50%) greater than 50 years had CR compared to 22 of 26 patients (85%) less than 50 years. CR rates were similar in community and university institutions.
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C D Buckner, and
A Fefer, and
Q DeMarsh, and
D Coleman, and
R B Dobrow, and
J Huff, and
C Kjobech, and
A S Hill, and
W Dittman, and
P E Neiman, and
M A Cheever, and
A B Einstein, and
E D Thomas
September 1981,
Cancer,
H Glucksberg, and
C D Buckner, and
A Fefer, and
Q DeMarsh, and
D Coleman, and
R B Dobrow, and
J Huff, and
C Kjobech, and
A S Hill, and
W Dittman, and
P E Neiman, and
M A Cheever, and
A B Einstein, and
E D Thomas
March 1972,
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H Glucksberg, and
C D Buckner, and
A Fefer, and
Q DeMarsh, and
D Coleman, and
R B Dobrow, and
J Huff, and
C Kjobech, and
A S Hill, and
W Dittman, and
P E Neiman, and
M A Cheever, and
A B Einstein, and
E D Thomas
November 1982,
Cancer treatment reports,
H Glucksberg, and
C D Buckner, and
A Fefer, and
Q DeMarsh, and
D Coleman, and
R B Dobrow, and
J Huff, and
C Kjobech, and
A S Hill, and
W Dittman, and
P E Neiman, and
M A Cheever, and
A B Einstein, and
E D Thomas
January 1985,
Haematology and blood transfusion,
H Glucksberg, and
C D Buckner, and
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Q DeMarsh, and
D Coleman, and
R B Dobrow, and
J Huff, and
C Kjobech, and
A S Hill, and
W Dittman, and
P E Neiman, and
M A Cheever, and
A B Einstein, and
E D Thomas
July 1983,
Cancer,
H Glucksberg, and
C D Buckner, and
A Fefer, and
Q DeMarsh, and
D Coleman, and
R B Dobrow, and
J Huff, and
C Kjobech, and
A S Hill, and
W Dittman, and
P E Neiman, and
M A Cheever, and
A B Einstein, and
E D Thomas
January 1983,
Advances in internal medicine,
H Glucksberg, and
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D Coleman, and
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C Kjobech, and
A S Hill, and
W Dittman, and
P E Neiman, and
M A Cheever, and
A B Einstein, and
E D Thomas
October 1974,
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H Glucksberg, and
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August 1992,
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November 1984,
Annals of internal medicine,
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W Dittman, and
P E Neiman, and
M A Cheever, and
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E D Thomas
January 1994,
Acta haematologica Polonica,
