[Postnatal development of evoked potentials in the rat somatosensory cortex]. 1995

M Seo, and I Uramoto
Department of Physiology, Institute for Developmental Research, Aichi Prefectural Colony.

The developmental changes of evoked potentials in the somatosensory cortex were studied using Long-Evans rats of postnatal age from day 2 to day 55. A hole of appropriate size was made in the skull under urethane anesthesia (1.4 g/kg) and somatosensory evoked potentials (SEPs) were recorded with a silver-ball electrode. Electrical stimulation was applied to whisker C 3 follicle. The electrode was moved on the dura over the hemisphere and SEPs were displayed on an oscilloscope. When a maximum SEP was obtained 100 successive responses were digitally processed with a time resolutions of 100 microseconds and averaged. From the averaged SEP, various peak latencies and amplitudes were calculated. In response to electrical stimulation of the whisker follicle, a short-latency positive wave appeared on postnatal day 2 (PND 2) and the second positive wave was recorded on PND 8 and a negative wave appeared on PND 10. The latency of these waves shortened, while the amplitude increased with age. SEPs in developing rats attained adult pattern on PND 17, although both the values of latency and amplitude reach the limit on PND 55. The placing reaction was also tested from PND 9 to PND 15 to examine the functional development of whisker. All subjects displayed positive placing reaction of chin hair on PND 10. At this age all components appeared in the SEP, 1st positive, 2nd positive and negative waves.

UI MeSH Term Description Entries
D008297 Male Males
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D002540 Cerebral Cortex The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulci. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions. Allocortex,Archipallium,Cortex Cerebri,Cortical Plate,Paleocortex,Periallocortex,Allocortices,Archipalliums,Cerebral Cortices,Cortex Cerebrus,Cortex, Cerebral,Cortical Plates,Paleocortices,Periallocortices,Plate, Cortical
D005073 Evoked Potentials, Somatosensory The electric response evoked in the CEREBRAL CORTEX by stimulation along AFFERENT PATHWAYS from PERIPHERAL NERVES to CEREBRUM. Somatosensory Evoked Potentials,Evoked Potential, Somatosensory,Somatosensory Evoked Potential
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000831 Animals, Newborn Refers to animals in the period of time just after birth. Animals, Neonatal,Animal, Neonatal,Animal, Newborn,Neonatal Animal,Neonatal Animals,Newborn Animal,Newborn Animals
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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