-transparent.png){kind=logo}
Twenty-five steroid-dependent severely asthmatic patients, ranging in age from 20 to 67 years, were hospitalized. Baseline laboratory and pulmonary function testing was followed by reduction of prednisone therapy to 5 mg daily and by entry into a randomized double-blind study of placebo vs active aerosol triamcinolone acetonide (300mug four times daily). In this four-week trial, aerosol triamcinolone acetonide further reversed airway obstruction and proved to be an effective substitute for large oral doses of steroids in steroid-dependent patients with severe asthma. No significant improvement occurred in the maximum midexpiratory flow or the maximum velocity of air flow after 50 percent or 75 percent of the vital capacity had been expelled. There was no significant difference in the frequency of untoward effects between the groups taking aerosol triamcinolone acetonide and its vehicle. No patient demonstrated any definite return of adrenal function.
R J Kriz, and
F Chmelik, and
G doPico, and
C E Reed
April 1977,
Arizona medicine,
R J Kriz, and
F Chmelik, and
G doPico, and
C E Reed
March 1977,
Annals of allergy,
R J Kriz, and
F Chmelik, and
G doPico, and
C E Reed
December 1975,
Chest,
R J Kriz, and
F Chmelik, and
G doPico, and
C E Reed
March 1980,
Annals of allergy,
R J Kriz, and
F Chmelik, and
G doPico, and
C E Reed
April 1979,
Thorax,
R J Kriz, and
F Chmelik, and
G doPico, and
C E Reed
August 1978,
The Journal of allergy and clinical immunology,
R J Kriz, and
F Chmelik, and
G doPico, and
C E Reed
November 1976,
The Journal of the Kansas Medical Society,
R J Kriz, and
F Chmelik, and
G doPico, and
C E Reed
December 1981,
Chest,
R J Kriz, and
F Chmelik, and
G doPico, and
C E Reed
May 1974,
The American review of respiratory disease,
R J Kriz, and
F Chmelik, and
G doPico, and
C E Reed
February 1961,
Archives of dermatology,
