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Cycloocta[b]pyran derivatives with local anesthetic, platelet antiaggregating and other activities. 1995
M Longobardi, and
A Bargagna, and
E Mariani, and
P Schenone, and
M D'Amico, and
M Falciani, and
W Filippelli, and
C Contaldi
Istituto di Farmacologia e Tossicologia, Facoltà di Medicina e Chirurgia, II Università degli studi di Napoli, Italy.
The synthesis of some N,N-disubstituted 4-amino-5,6,7,8,9,10-hexahydro-3- phenyl-2H-cycloocta[b]pyran-2-ones by reaction of phenylchloroketene with a series of N,N-disubstituted 2-aminomethylenecyclooctanones, followed by dehydrochlorination in situ of the primary adducts with DBN, is described. The dimethylamino derivative showed a local anesthetic activity in mice superior to that of lidocaine, and some compounds exhibited a platelet antiaggregating activity in vitro superior or comparable to that of acetylsalicylic acid, as well as weak antiarrhythmic and antiinflammatory activities in rats.
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Farmaco (Societa chimica italiana : 1989),
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A Bargagna, and
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P Schenone, and
M D'Amico, and
M Falciani, and
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