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The effects of attenuated rubella virus infection upon cell-mediated immunity of human volunteers were studied. The volunteers received the vaccine either by nose drops or by the subcutaneous route. Changes in cell-mediated immunity in terms of delayed cutaneous sensitivity to recall antigens, phytohemagglutination stimulation, and spontaneous migration inhibitory factor-like activity were studied at various time periods after infection. Spontaneous migration inhibitory factor-like activity was studied on supernatants of the lymphocytes obtained from the volunteers and incubated for 72 h in the absence of any antigens. A significant proportion of the volunteers showed suppression of one or more parameters of cell-medicated immunity tested by week 2 of infection compared to the control; however, there was no correlation between suppression of the various parameters studied. No difference was noticed in the incidence of cell-mediated immunity suppression between nose drops and subcutaneous route groups.
R Ganguly, and
C L Cusumano, and
R H Waldman
March 1977,
Canadian Medical Association journal,
R Ganguly, and
C L Cusumano, and
R H Waldman
January 1992,
Microbiology and immunology,
R Ganguly, and
C L Cusumano, and
R H Waldman
April 1975,
The Journal of infectious diseases,
R Ganguly, and
C L Cusumano, and
R H Waldman
December 1976,
Cancer research,
R Ganguly, and
C L Cusumano, and
R H Waldman
September 1980,
The Journal of infectious diseases,
R Ganguly, and
C L Cusumano, and
R H Waldman
June 1977,
The Journal of experimental medicine,
R Ganguly, and
C L Cusumano, and
R H Waldman
September 1980,
Bollettino della Societa italiana di biologia sperimentale,
R Ganguly, and
C L Cusumano, and
R H Waldman
September 1977,
The Indian journal of medical research,
R Ganguly, and
C L Cusumano, and
R H Waldman
September 1973,
The New England journal of medicine,
R Ganguly, and
C L Cusumano, and
R H Waldman
January 1975,
Scandinavian journal of immunology,
