Biomaterial Database

Regulation of posterior lateral hypothalamic arousal related neuronal discharge by preoptic anterior hypothalamic warming. 1994

B L Krilowicz, and R Szymusiak, and D McGinty

Department of Biology and Microbiology, State University California, Los Angeles 90032, USA.

The posterior lateral hypothalamus (PLH) is a brain region involved in cortical activation and maintenance of behavioral arousal. Spontaneous and evoked neuronal activities were recorded in the PLH of cats before and during local warming of the preoptic-anterior hypothalamus (POAH). Forty-six percent of PLH neurons recorded in awake cats decreased spontaneous discharge during POAH warming. In the absence of POAH warming, these same cells exhibited significantly lower discharge rates in non-rapid eye movement (NREM) sleep compared to waking. Responses of PLH neurons to POAH warming were also investigated in sleeping cats to determine whether hypothalamic thermosensitive neurons modulated sleep-wake regulation across arousal states. POAH warming had no influence on spontaneous activities of PLH neurons during NREM sleep, but suppressed activity of a small subset of neurons during rapid eye movement (REM) sleep. Thus, during wakefulness or REM sleep, hypothalamic thermosensitive neurons may modulate behavioral state via inhibition or disfacilitation of arousal systems.

UI	MeSH Term	Description	Entries
D007032	Hypothalamus, Anterior	The front portion of the HYPOTHALAMUS separated into the preoptic region and the supraoptic region. The preoptic region is made up of the periventricular GRAY MATTER of the rostral portion of the THIRD VENTRICLE and contains the preoptic ventricular nucleus and the medial preoptic nucleus. The supraoptic region contains the PARAVENTRICULAR HYPOTHALAMIC NUCLEUS, the SUPRAOPTIC NUCLEUS, the ANTERIOR HYPOTHALAMIC NUCLEUS, and the SUPRACHIASMATIC NUCLEUS.	Hypothalamus, Supraoptic,Anterior Hypothalamic Commissure,Anterior Hypothalamic Decussation of Ganser,Anteroventral Periventricular Nucleus,Anterior Hypothalamic Commissures,Anterior Hypothalamus,Commissure, Anterior Hypothalamic,Commissures, Anterior Hypothalamic,Hypothalamic Commissure, Anterior,Hypothalamic Commissures, Anterior,Nucleus, Anteroventral Periventricular,Periventricular Nucleus, Anteroventral,Supraoptic Hypothalamus
D007034	Hypothalamus, Posterior	The part of the hypothalamus posterior to the middle region consisting of several nuclei including the medial maxillary nucleus, lateral mammillary nucleus, and posterior hypothalamic nucleus (posterior hypothalamic area). The posterior hypothalamic area is concerned with control of sympathetic responses and is sensitive to conditions of decreasing temperature and controls the mechanisms for the conservation and increased production of heat.	Hypothalamic Region, Posterior,Posterior Hypothalamic Region,Area Hypothalamica Posterior,Hypothalamus Posterior,Mammillary Region,Posterior Hypothalamus,Posterior Periventricular Nucleus,Premammillary Nucleus,Supramammillary Commissure,Supramammillary Nucleus,Area Hypothalamica Posteriors,Commissure, Supramammillary,Commissures, Supramammillary,Hypothalamic Regions, Posterior,Hypothalamica Posterior, Area,Hypothalamica Posteriors, Area,Hypothalamus Posteriors,Mammillary Regions,Nucleus, Posterior Periventricular,Nucleus, Premammillary,Nucleus, Supramammillary,Periventricular Nucleus, Posterior,Posterior Hypothalamic Regions,Posterior, Area Hypothalamica,Posterior, Hypothalamus,Posteriors, Area Hypothalamica,Posteriors, Hypothalamus,Region, Mammillary,Region, Posterior Hypothalamic,Regions, Mammillary,Regions, Posterior Hypothalamic,Supramammillary Commissures
D001833	Body Temperature Regulation	The processes of heating and cooling that an organism uses to control its temperature.	Heat Loss,Thermoregulation,Regulation, Body Temperature,Temperature Regulation, Body,Body Temperature Regulations,Heat Losses,Loss, Heat,Losses, Heat,Regulations, Body Temperature,Temperature Regulations, Body,Thermoregulations
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D003627	Data Interpretation, Statistical	Application of statistical procedures to analyze specific observed or assumed facts from a particular study.	Data Analysis, Statistical,Data Interpretations, Statistical,Interpretation, Statistical Data,Statistical Data Analysis,Statistical Data Interpretation,Analyses, Statistical Data,Analysis, Statistical Data,Data Analyses, Statistical,Interpretations, Statistical Data,Statistical Data Analyses,Statistical Data Interpretations
D005071	Evoked Potentials	Electrical responses recorded from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported.	Event Related Potential,Event-Related Potentials,Evoked Potential,N100 Evoked Potential,P50 Evoked Potential,N1 Wave,N100 Evoked Potentials,N2 Wave,N200 Evoked Potentials,N3 Wave,N300 Evoked Potentials,N4 Wave,N400 Evoked Potentials,P2 Wave,P200 Evoked Potentials,P50 Evoked Potentials,P50 Wave,P600 Evoked Potentials,Potentials, Event-Related,Event Related Potentials,Event-Related Potential,Evoked Potential, N100,Evoked Potential, N200,Evoked Potential, N300,Evoked Potential, N400,Evoked Potential, P200,Evoked Potential, P50,Evoked Potential, P600,Evoked Potentials, N100,Evoked Potentials, N200,Evoked Potentials, N300,Evoked Potentials, N400,Evoked Potentials, P200,Evoked Potentials, P50,Evoked Potentials, P600,N1 Waves,N2 Waves,N200 Evoked Potential,N3 Waves,N300 Evoked Potential,N4 Waves,N400 Evoked Potential,P2 Waves,P200 Evoked Potential,P50 Waves,P600 Evoked Potential,Potential, Event Related,Potential, Event-Related,Potential, Evoked,Potentials, Event Related,Potentials, Evoked,Potentials, N400 Evoked,Related Potential, Event,Related Potentials, Event,Wave, N1,Wave, N2,Wave, N3,Wave, N4,Wave, P2,Wave, P50,Waves, N1,Waves, N2,Waves, N3,Waves, N4,Waves, P2,Waves, P50
D005133	Eye Movements	Voluntary or reflex-controlled movements of the eye.	Eye Movement,Movement, Eye,Movements, Eye
D006358	Hot Temperature	Presence of warmth or heat or a temperature notably higher than an accustomed norm.	Heat,Hot Temperatures,Temperature, Hot,Temperatures, Hot
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001143	Arousal	Cortical vigilance or readiness of tone, presumed to be in response to sensory stimulation via the reticular activating system.	Vigilance, Cortical,Arousals,Cortical Vigilance