Biomaterial Database

Iron and copper metabolism in analbuminaemic rats fed a high-iron diet. 1995

S Yu, and R B Beems, and J A Joles, and G A Kaysen, and A C Beynen

Department of Human Nutrition, Wageningen Agricultural University, The Netherlands.

The metabolism of iron and copper in male Nagase analbuminaemic (NA) and Sprague Dawley (SD) rats was compared. Relative liver weight was higher and spleen weight significantly lower in NA than SD rats. In NA rats, red blood cell count, haemoglobin and haematocrit were lower, whereas plasma transferrin, total iron-binding capacity and mean corpuscular haemoglobin were higher when compared with SD rats. Iron concentrations in plasma, liver, kidneys and heart were higher, and those in the spleen and tibia were lower, in NA rats. The iron concentrations in liver and spleen were positively correlated with the amount of brown pigment as observed histopathologically. Bile flow as well as biliary iron and copper excretion were higher in NA than SD rats. Copper concentrations in liver, kidneys and plasma were higher in NA rats. Plasma levels of ceruloplasmin were about two-fold higher in NA rats. The feeding of a high-iron diet reduced kidney copper concentrations in both strains of rats, which was associated with a decrease in the absorption and biliary excretion of copper.

UI	MeSH Term	Description	Entries
D007408	Intestinal Absorption	Uptake of substances through the lining of the INTESTINES.	Absorption, Intestinal
D007501	Iron	A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.	Iron-56,Iron 56
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D011919	Rats, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.	August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D003300	Copper	A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.	Copper-63,Copper 63
D004032	Diet	Regular course of eating and drinking adopted by a person or animal.	Diets
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001646	Bile	An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.	Biliary Sludge,Sludge, Biliary

Related Publications

S Yu, and R B Beems, and J A Joles, and G A Kaysen, and A C Beynen

Copper metabolism in analbuminaemic rats fed a high-copper diet.

March 1995, Comparative biochemistry and physiology. Part A, Physiology,

S Yu, and R B Beems, and J A Joles, and G A Kaysen, and A C Beynen

The effect of copper and protein on iron metabolism in rats fed a cereal diet.

August 1981, The Science of the total environment,

S Yu, and R B Beems, and J A Joles, and G A Kaysen, and A C Beynen

Plasma proteins in growing analbuminaemic rats fed on a diet of low-protein content.

May 1989, The British journal of nutrition,

S Yu, and R B Beems, and J A Joles, and G A Kaysen, and A C Beynen

Excessive hepatic copper accumulation in jaundiced rats fed a high-copper diet.

September 2002, Biological trace element research,

S Yu, and R B Beems, and J A Joles, and G A Kaysen, and A C Beynen

Copper homeostasis in rats fed on a high-sulphide diet.

December 1996, The British journal of nutrition,

S Yu, and R B Beems, and J A Joles, and G A Kaysen, and A C Beynen

Modification of vitamin A metabolism in rats fed a copper-deficient diet.

January 1987, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,

S Yu, and R B Beems, and J A Joles, and G A Kaysen, and A C Beynen

Analyses of hemorrhagic diathesis in high-iron diet-fed rats.

January 2021, Journal of toxicologic pathology,

S Yu, and R B Beems, and J A Joles, and G A Kaysen, and A C Beynen

Embryonic loss and progesterone metabolism in rats fed a high energy diet.

February 1977, The Journal of nutrition,

S Yu, and R B Beems, and J A Joles, and G A Kaysen, and A C Beynen

Dietary fiber and cholesterol metabolism in rats fed a high cholesterol diet.

May 1979, Atherosclerosis,

S Yu, and R B Beems, and J A Joles, and G A Kaysen, and A C Beynen

Metabolism of Sr-90 in rats fed high-calcium diet.

January 1966, Federation proceedings. Translation supplement; selected translations from medical-related science,