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Several authors have described increased Na-H exchanger activity in essential hypertension but no data are available in secondary forms of hypertension such as primary aldosteronism. We measured Na-H exchanger kinetics together with Na-Li countertransport Vmax in the erythrocytes of eight patients with primary aldosteronism and in 15 normotensive control subjects. Plasma aldosterone, plasma renin and plasma potassium were also evaluated. Na-H exchanger Vmax appear to be increased in patients with primary aldosteronism and Hill's n, an index of co-operativity amongst intracellular proton binding sites, was significantly lower in patients than in controls. No statistically significant differences were found between affinity for intracellular protons (K50%) and for Na-Li countertransport Vmax between the two groups studied. We were unable to find any correlations between Na-H exchanger Vmax and Na-Li countertransport Vmax in the two groups considered as a whole. From the present data Na-H exchanger overactivity would not appear to be a specific feature of essential hypertension but seems to be characteristic in patients with primary aldosteronism.
P Delva, and
C Pastori, and
M Degan, and
G Montesi, and
A Bassi, and
A Lechi
January 1998,
Nihon rinsho. Japanese journal of clinical medicine,
P Delva, and
C Pastori, and
M Degan, and
G Montesi, and
A Bassi, and
A Lechi
July 2000,
Kidney international,
P Delva, and
C Pastori, and
M Degan, and
G Montesi, and
A Bassi, and
A Lechi
December 1998,
Journal of the American Society of Nephrology : JASN,
P Delva, and
C Pastori, and
M Degan, and
G Montesi, and
A Bassi, and
A Lechi
January 1993,
Biology of the neonate,
P Delva, and
C Pastori, and
M Degan, and
G Montesi, and
A Bassi, and
A Lechi
January 1986,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
P Delva, and
C Pastori, and
M Degan, and
G Montesi, and
A Bassi, and
A Lechi
December 1990,
Acta paediatrica Scandinavica,
P Delva, and
C Pastori, and
M Degan, and
G Montesi, and
A Bassi, and
A Lechi
October 1997,
Biochemical and molecular medicine,
P Delva, and
C Pastori, and
M Degan, and
G Montesi, and
A Bassi, and
A Lechi
January 1996,
The Chinese journal of physiology,
P Delva, and
C Pastori, and
M Degan, and
G Montesi, and
A Bassi, and
A Lechi
September 1999,
Clinical science (London, England : 1979),
P Delva, and
C Pastori, and
M Degan, and
G Montesi, and
A Bassi, and
A Lechi
June 1993,
American journal of hypertension,
