-transparent.png){kind=logo}
Alcohol-induced cirrhosis (AC) is accompanied by disturbances of immune function and cytokine production. To better define the pattern of cytokine synthesis in this disease and to relate it to the immune activation state, we measured circulating levels of soluble tumor necrosis factor receptor p55 (sTNFR-55) and neopterin in a group of 85 patients with AC (classified according to the Child-Pugh score of severity of liver disease) and 43 healthy volunteers. Serum concentrations of sTNFR-55 and neopterin were significantly raised in patients with AC. Moreover, concentrations of sTNFR-55 were significantly higher in patients with more severe disease compared with the group with lower severity. There were significant correlations between sTNFR-55 and neopterin levels in patients and controls. The results contribute to affirm the existence of an immune activation state in AC that could be responsible for the development of the disease and clinical complications.
A Diez-Ruiz, and
G P Tilz, and
F Gutierrez-Gea, and
B Gil-Extremera, and
C Murr, and
H Wachter, and
D Fuchs
September 2009,
Journal of pharmaceutical sciences,
A Diez-Ruiz, and
G P Tilz, and
F Gutierrez-Gea, and
B Gil-Extremera, and
C Murr, and
H Wachter, and
D Fuchs
August 2005,
Nihon rinsho. Japanese journal of clinical medicine,
A Diez-Ruiz, and
G P Tilz, and
F Gutierrez-Gea, and
B Gil-Extremera, and
C Murr, and
H Wachter, and
D Fuchs
April 1997,
The Journal of rheumatology,
A Diez-Ruiz, and
G P Tilz, and
F Gutierrez-Gea, and
B Gil-Extremera, and
C Murr, and
H Wachter, and
D Fuchs
July 2002,
Veterinary immunology and immunopathology,
A Diez-Ruiz, and
G P Tilz, and
F Gutierrez-Gea, and
B Gil-Extremera, and
C Murr, and
H Wachter, and
D Fuchs
March 2000,
Cellular immunology,
A Diez-Ruiz, and
G P Tilz, and
F Gutierrez-Gea, and
B Gil-Extremera, and
C Murr, and
H Wachter, and
D Fuchs
February 2003,
Neurobiology of disease,
A Diez-Ruiz, and
G P Tilz, and
F Gutierrez-Gea, and
B Gil-Extremera, and
C Murr, and
H Wachter, and
D Fuchs
October 2000,
The Annals of thoracic surgery,
A Diez-Ruiz, and
G P Tilz, and
F Gutierrez-Gea, and
B Gil-Extremera, and
C Murr, and
H Wachter, and
D Fuchs
January 2004,
Terapevticheskii arkhiv,
A Diez-Ruiz, and
G P Tilz, and
F Gutierrez-Gea, and
B Gil-Extremera, and
C Murr, and
H Wachter, and
D Fuchs
July 2010,
Nihon rinsho. Japanese journal of clinical medicine,
A Diez-Ruiz, and
G P Tilz, and
F Gutierrez-Gea, and
B Gil-Extremera, and
C Murr, and
H Wachter, and
D Fuchs
April 2009,
The journal of obstetrics and gynaecology research,
