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The pharmacokinetics of once daily gentamicin in neutropenic adults with haematological malignancy. 1994
A P MacGowan, and
K A Bedford, and
E Blundell, and
N M Brown, and
F Habib, and
J Hows, and
B Kirkpatrick, and
R J Korner, and
R R Slade, and
L O White
Department of Medical Microbiology, Southmead Health Services NHS Trust, Westbury-on-Trym, Bristol, UK.
Seven febrile neutropenic adults with normal renal function were treated with intravenous gentamicin 4.5 mg/kg once a day in combination with azlocillin. Gentamicin serum concentrations 1, 2, 4, 8, and 24 h after a 30 min infusion were 10.9 +/- 0.6, 7.1 +/- 0.4, 4.2 +/- 0.2, 1.8 +/- 0.1 and 0.16 +/- 0.003 mg/L respectively. The pharmacokinetics were best described by a triphasic plot including a distribution phase (about 1/2 h) and two elimination phases, an early and late.
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