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OBJECTIVE To investigate the effects of hypochlorhydria and acidic drink ingestion on protein-bound vitamin B12 absorption in elderly subjects. METHODS Absorption of protein-bound vitamin B12 was examined in elderly normal subjects (n = 8), and in hypochlorhydric subjects due to omeprazole treatment (n = 8) or with atrophic gastritis (n = 3). Subjects underwent absorption tests of protein-bound vitamin B12 ingested with water, cranberry juice and 0.1 N hydrochloric acid. RESULTS Protein-bound vitamin B12 absorption was lower in the omeprazole-treated group (0.50%) compared to the normal group (1.21%; p < 0.001). With cranberry juice ingestion, the omeprazole-treated group showed an increase in absorbed protein-bound vitamin B12 (p = 0.025). With dilute hydrochloric acid ingestion, there was a further increase in vitamin B12 absorption (p < 0.001). CONCLUSIONS Omeprazole causes protein-bound vitamin B12 malabsorption, and ingestion of an acidic drink improves protein-bound vitamin B12 absorption.
J R Saltzman, and
J A Kemp, and
B B Golner, and
M C Pedrosa, and
G E Dallal, and
R M Russell
June 1957,
Acta medica Scandinavica,
J R Saltzman, and
J A Kemp, and
B B Golner, and
M C Pedrosa, and
G E Dallal, and
R M Russell
October 1991,
Gastroenterology,
J R Saltzman, and
J A Kemp, and
B B Golner, and
M C Pedrosa, and
G E Dallal, and
R M Russell
October 1999,
Alimentary pharmacology & therapeutics,
J R Saltzman, and
J A Kemp, and
B B Golner, and
M C Pedrosa, and
G E Dallal, and
R M Russell
April 1988,
Journal of clinical pathology,
J R Saltzman, and
J A Kemp, and
B B Golner, and
M C Pedrosa, and
G E Dallal, and
R M Russell
May 1987,
Journal of the American Geriatrics Society,
J R Saltzman, and
J A Kemp, and
B B Golner, and
M C Pedrosa, and
G E Dallal, and
R M Russell
January 2021,
Case reports in hematology,
J R Saltzman, and
J A Kemp, and
B B Golner, and
M C Pedrosa, and
G E Dallal, and
R M Russell
November 1960,
Australasian annals of medicine,
J R Saltzman, and
J A Kemp, and
B B Golner, and
M C Pedrosa, and
G E Dallal, and
R M Russell
January 1969,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
J R Saltzman, and
J A Kemp, and
B B Golner, and
M C Pedrosa, and
G E Dallal, and
R M Russell
May 1985,
Chinese medical journal,
J R Saltzman, and
J A Kemp, and
B B Golner, and
M C Pedrosa, and
G E Dallal, and
R M Russell
November 1960,
The American journal of digestive diseases,
