Seasonal variation of vitamin A (retinol) status in older men and women. 1994

T K Basu, and E A Donald, and J A Hargreaves, and G W Thompson, and E Chao, and R D Peterson
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada.

OBJECTIVE The present study was undertaken to determine vitamin A status in 59 free-living (26 males, 33 females) healthy older persons (65-74 years) in winter and summer. METHODS Three-day dietary intake data for vitamin A along with carbohydrate, lipid and protein were collected during the summer (June-September) and again during the winter (November-March). In addition, retinol and its carrier proteins, retinol-binding protein (RBP) and transthyretin (TTR), were measured in the plasma in each season. RESULTS The mean vitamin A intake met the Canadian Recommended Intake (RNI) for both gender and season. However, probability analysis of dietary data revealed that 7 and 11% of males, and 8 and 14% of females, in summer and winter, respectively, were at risk of deficiency. None of the subjects in the present study exhibited biochemical evidence of vitamin A deficiency as determined by plasma levels of retinol and its transport proteins. Overall, the mean intake of vitamin A was significantly higher in males than in females; no seasonal effect was observed. On the other hand, the plasma levels of retinol and its carrier proteins were significantly lower in winter season than in summer, without any gender variation effect. CONCLUSIONS Although mean values for dietary intake and plasma concentration of vitamin A may indicate nutritional adequacy, a small proportion of an older population may be at nutritional risk. The prevalence of risk appears to be generally higher in the winter than in the summer season and in females than in males.

UI MeSH Term Description Entries
D008297 Male Males
D011228 Prealbumin A tetrameric protein, molecular weight between 50,000 and 70,000, consisting of 4 equal chains, and migrating on electrophoresis in 3 fractions more mobile than serum albumin. Its concentration ranges from 7 to 33 per cent in the serum, but levels decrease in liver disease. Proalbumin,Transthyretin
D002851 Chromatography, High Pressure Liquid Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed. Chromatography, High Performance Liquid,Chromatography, High Speed Liquid,Chromatography, Liquid, High Pressure,HPLC,High Performance Liquid Chromatography,High-Performance Liquid Chromatography,UPLC,Ultra Performance Liquid Chromatography,Chromatography, High-Performance Liquid,High-Performance Liquid Chromatographies,Liquid Chromatography, High-Performance
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging
D012177 Retinol-Binding Proteins Proteins which bind with RETINOL. The retinol-binding protein found in plasma has an alpha-1 mobility on electrophoresis and a molecular weight of about 21 kDa. The retinol-protein complex (MW Retinoid Binding Protein,Retinol Binding Protein,Retinoid Binding Protein, F-Type,Retinoid Binding Proteins,Retinol Binding Proteins,Binding Protein, Retinoid,Binding Protein, Retinol,Binding Proteins, Retinoid,Binding Proteins, Retinol,Protein, Retinoid Binding,Protein, Retinol Binding,Retinoid Binding Protein, F Type
D012621 Seasons Divisions of the year according to some regularly recurrent phenomena usually astronomical or climatic. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Seasonal Variation,Season,Seasonal Variations,Variation, Seasonal,Variations, Seasonal
D012727 Sex Characteristics Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction. Gender Characteristics,Gender Differences,Gender Dimorphism,Sex Differences,Sex Dimorphism,Sexual Dichromatism,Sexual Dimorphism,Characteristic, Gender,Characteristic, Sex,Dichromatism, Sexual,Dichromatisms, Sexual,Difference, Sex,Dimorphism, Gender,Dimorphism, Sex,Dimorphism, Sexual,Gender Characteristic,Gender Difference,Gender Dimorphisms,Sex Characteristic,Sex Difference,Sex Dimorphisms,Sexual Dichromatisms,Sexual Dimorphisms

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