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OBJECTIVE The present study investigated the antagonism of the amino-terminal heptapeptide fragment of angiotensin II ([des-Phe8]-angiotensin II; Ang(1-7)) to angiotensin II (Ang II) both in vitro in rabbit aortae and in vivo in rats. RESULTS In rabbit isolated endothelium intact aortic rings Ang(1-7) caused a concentration-related rightward displacement of the Ang II curve and depressed the maximum response to Ang II. By applying the data to a Schild plot an apparent pA2 of 5.5 was calculated. This depression of maximum response could be reversed by co-incubation of Ang(1-7) with the competitive angiotensin antagonist losartan. Ang(1-7) had no effect on the contractile responses of several other agonists. Intravenous infusion of 10 or 100 micrograms/kg per min Ang(1-7) had no effect on the resting blood pressure in the anaesthetized rat but inhibited Ang II-induced pressor responses. CONCLUSIONS The present results show that Ang(1-7) is a specific non-competitive antagonist of Ang II at type 1 angiotensin II receptors.
J M Mahon, and
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I W Henderson
January 1999,
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J M Mahon, and
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March 1998,
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
J M Mahon, and
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J M Mahon, and
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I W Henderson
December 2016,
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J M Mahon, and
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FEBS letters,
J M Mahon, and
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I W Henderson
April 2005,
Circulation,
J M Mahon, and
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I W Henderson
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J M Mahon, and
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June 1998,
Journal of the American Society of Nephrology : JASN,
J M Mahon, and
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May 2009,
Reviews on recent clinical trials,
J M Mahon, and
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A K Nicol, and
I W Henderson
October 2003,
Regulatory peptides,
