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The physiological factors which induce and maintain mammalian sperm maturation and motility generally remain unclear, although several agents are known to be involved. We describe here the application of immunocytochemical and immunoblotting methods to identify the angiotensin II type 1 (AT1) receptor in the tails of ejaculated rat and human sperm. Motility data on stimulated and unstimulated sperm from volunteers and patients attending fertility clinics showed that angiotensin II may increase both the percentage of motile sperm and their linear velocity, while the specific AT1 receptor antagonist DuP753 inhibited the action of angiotensin II on the percentage of motile sperm. In rat seminiferous tubules, AT1 receptors were present in primary spermatogonia and in spermatid tails, but immunoreactivity was not seen in sperm contained in caput or cauda epididymis, showing that AT1 receptor function is regulated during transit through the reproductive tract. Since local tissue reninangiotensin systems are present in both male and female tracts, the data suggest that angiotensin II has a role in the maintenance of sperm function and fertility.
G P Vinson, and
J R Puddefoot, and
M M Ho, and
S Barker, and
J Mehta, and
E Saridogan, and
O Djahanbakhch
May 1991,
European journal of pharmacology,
G P Vinson, and
J R Puddefoot, and
M M Ho, and
S Barker, and
J Mehta, and
E Saridogan, and
O Djahanbakhch
July 2015,
Molecular medicine reports,
G P Vinson, and
J R Puddefoot, and
M M Ho, and
S Barker, and
J Mehta, and
E Saridogan, and
O Djahanbakhch
January 1995,
Endocrine research,
G P Vinson, and
J R Puddefoot, and
M M Ho, and
S Barker, and
J Mehta, and
E Saridogan, and
O Djahanbakhch
October 1999,
Regulatory peptides,
G P Vinson, and
J R Puddefoot, and
M M Ho, and
S Barker, and
J Mehta, and
E Saridogan, and
O Djahanbakhch
July 2020,
Cells,
G P Vinson, and
J R Puddefoot, and
M M Ho, and
S Barker, and
J Mehta, and
E Saridogan, and
O Djahanbakhch
February 1999,
The Journal of pharmacology and experimental therapeutics,
G P Vinson, and
J R Puddefoot, and
M M Ho, and
S Barker, and
J Mehta, and
E Saridogan, and
O Djahanbakhch
August 2002,
Fundamental & clinical pharmacology,
G P Vinson, and
J R Puddefoot, and
M M Ho, and
S Barker, and
J Mehta, and
E Saridogan, and
O Djahanbakhch
May 1995,
The Journal of clinical investigation,
G P Vinson, and
J R Puddefoot, and
M M Ho, and
S Barker, and
J Mehta, and
E Saridogan, and
O Djahanbakhch
March 2006,
Hypertension (Dallas, Tex. : 1979),
G P Vinson, and
J R Puddefoot, and
M M Ho, and
S Barker, and
J Mehta, and
E Saridogan, and
O Djahanbakhch
August 1993,
Japanese journal of pharmacology,
