-transparent.png){kind=logo}
The immunisation of sheep with inactivated Cowdria ruminantium organisms (the causative agent of heartwater) emulsified in Freund's adjuvant induced protective immunity against a homologous challenge with virulent cell culture-derived C ruminantium organisms. This protective immunity was associated with the development of high titres of C ruminantium-specific antibodies, a low level of rickettsiosis in brain endothelium and no mortalities. In contrast, when unimmunised sheep were challenged, they developed higher levels of rickettsiosis in brain endothelium, and some of them died. This method of immunisation against heartwater has the potential to replace the infection and treatment method that is in current use.
S M Mahan, and
H R Andrew, and
N Tebele, and
M J Burridge, and
A F Barbet
May 1994,
Veterinary immunology and immunopathology,
S M Mahan, and
H R Andrew, and
N Tebele, and
M J Burridge, and
A F Barbet
December 1996,
Veterinary parasitology,
S M Mahan, and
H R Andrew, and
N Tebele, and
M J Burridge, and
A F Barbet
November 2007,
Vaccine,
S M Mahan, and
H R Andrew, and
N Tebele, and
M J Burridge, and
A F Barbet
January 1983,
Advances in veterinary science and comparative medicine,
S M Mahan, and
H R Andrew, and
N Tebele, and
M J Burridge, and
A F Barbet
January 1993,
Revue d'elevage et de medecine veterinaire des pays tropicaux,
S M Mahan, and
H R Andrew, and
N Tebele, and
M J Burridge, and
A F Barbet
December 1979,
Journal of the South African Veterinary Association,
S M Mahan, and
H R Andrew, and
N Tebele, and
M J Burridge, and
A F Barbet
July 1998,
Vaccine,
S M Mahan, and
H R Andrew, and
N Tebele, and
M J Burridge, and
A F Barbet
January 1982,
The veterinary quarterly,
S M Mahan, and
H R Andrew, and
N Tebele, and
M J Burridge, and
A F Barbet
April 1992,
Journal of clinical microbiology,
S M Mahan, and
H R Andrew, and
N Tebele, and
M J Burridge, and
A F Barbet
February 1985,
The Veterinary record,
