Sex determination in a symmetric autosomal multi-locus model. 1995

F B Christiansen, and M W Feldman
Department of Ecology and Genetics, University of Aarhus, Denmark.

A model of determination of sex by an individual's genotype at n loci is discussed. The parameters that determine the probability that an individual is male (or female) depend only on the loci at which the individual is heterozygous, extending the two-gene theory of Feldman et al. (1991, Genetics 129, 297-312). The analysis uses a set indexation technique that allows a compact expression of the recombination process, and a transformation of the chromosome frequencies that induces a natural subgroup structure on hyperplanes in the frequency simplex. It is shown that the polymorphic equilibria correspond to these subgroups. Conditions are determined under which equilibria that exhibit the even sex ratio are stable. How recombination affects the stability of other equilibria, including those with linkage disequilibrium, are also explored.

UI MeSH Term Description Entries
D008297 Male Males
D008957 Models, Genetic Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment. Genetic Models,Genetic Model,Model, Genetic
D002874 Chromosome Mapping Any method used for determining the location of and relative distances between genes on a chromosome. Gene Mapping,Linkage Mapping,Genome Mapping,Chromosome Mappings,Gene Mappings,Genome Mappings,Linkage Mappings,Mapping, Chromosome,Mapping, Gene,Mapping, Genome,Mapping, Linkage,Mappings, Chromosome,Mappings, Gene,Mappings, Genome,Mappings, Linkage
D005260 Female Females
D005787 Gene Frequency The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION. Allele Frequency,Genetic Equilibrium,Equilibrium, Genetic,Allele Frequencies,Frequencies, Allele,Frequencies, Gene,Frequency, Allele,Frequency, Gene,Gene Frequencies
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012641 Selection, Genetic Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population. Natural Selection,Genetic Selection,Selection, Natural
D012732 Sex Determination Analysis Validation of the SEX of an individual by inspection of the GONADS and/or by genetic tests. Sex Determination Techniques,Sex Determination Technics,Analyses, Sex Determination,Analysis, Sex Determination,Sex Determination Analyses,Sex Determination Technic,Sex Determination Technique,Technic, Sex Determination,Technics, Sex Determination,Technique, Sex Determination,Techniques, Sex Determination
D012744 Sex Ratio The number of males per 100 females. Ratio, Sex,Ratios, Sex,Sex Ratios
D015810 Linkage Disequilibrium Nonrandom association of linked genes. This is the tendency of the alleles of two separate but already linked loci to be found together more frequently than would be expected by chance alone. Disequilibrium, Linkage,Disequilibriums, Linkage,Linkage Disequilibriums

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