-transparent.png){kind=logo}
OBJECTIVE This study was done to assess the effects of temperature on bleeding time and clotting time in normal male and female volunteers. METHODS Open study utilizing normal volunteers. METHODS University research laboratory. METHODS Fifty-four healthy male and female volunteers, ranging in age from 19 to 35 yrs, who were not receiving medications. The study was done and the samples of venous blood and shed blood collected at the template bleeding time site were obtained at a convenient time for each volunteer. METHODS Skin temperature was changed from +20 degrees to +38 degrees C and blood samples were obtained from the antecubital vein of each volunteer. RESULTS The effect of local skin temperature ranging from +20 degrees to +38 degrees C on bleeding time was evaluated in 38 normal volunteers (19 male and 19 female). Skin temperature was maintained at +20 degrees to +38 degrees C by cooling or warming the forearm. At each temperature, measurements were made of complete blood count, bleeding time, and thromboxane B2 concentrations in shed blood collected at the template bleeding time site and in serum and plasma isolated from blood collected from the antecubital vein. Clotting time studies were measured in 16 normal volunteers (eight male and eight female) at temperatures ranging from +22 degrees to +37 degrees C. At +32 degrees C, the bleeding time was longer and hematocrit was lower in female than in male volunteers. However, at local skin temperatures of < +32 degrees C, both the males and females exhibited significantly increased bleeding times, which were associated with a reduction in shed blood thromboxane B2. Each 1 degree C decrease in temperature was associated with a 15% decrease in the shed blood thromboxane B2 concentration. Clotting times were three times longer at +22 degrees C than at +37 degrees C. Each 1 degree C reduction in the temperature of the clotted blood was associated with a 15% reduction in the serum thromboxane B2 concentration. CONCLUSIONS Our data indicate that during surgical procedures, it is important to maintain normothermia to ensure that platelets and clotting proteins function optimally.
C R Valeri, and
H MacGregor, and
G Cassidy, and
R Tinney, and
F Pompei
January 1992,
International journal of clinical & laboratory research,
C R Valeri, and
H MacGregor, and
G Cassidy, and
R Tinney, and
F Pompei
October 1999,
Scandinavian journal of clinical and laboratory investigation,
C R Valeri, and
H MacGregor, and
G Cassidy, and
R Tinney, and
F Pompei
December 2020,
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria,
C R Valeri, and
H MacGregor, and
G Cassidy, and
R Tinney, and
F Pompei
May 1983,
The Journal of antimicrobial chemotherapy,
C R Valeri, and
H MacGregor, and
G Cassidy, and
R Tinney, and
F Pompei
July 1981,
Endokrinologie,
C R Valeri, and
H MacGregor, and
G Cassidy, and
R Tinney, and
F Pompei
January 1985,
Methods and findings in experimental and clinical pharmacology,
C R Valeri, and
H MacGregor, and
G Cassidy, and
R Tinney, and
F Pompei
June 1969,
Canadian Medical Association journal,
C R Valeri, and
H MacGregor, and
G Cassidy, and
R Tinney, and
F Pompei
August 1969,
Canadian Medical Association journal,
C R Valeri, and
H MacGregor, and
G Cassidy, and
R Tinney, and
F Pompei
May 1985,
Antimicrobial agents and chemotherapy,
C R Valeri, and
H MacGregor, and
G Cassidy, and
R Tinney, and
F Pompei
April 1995,
The Journal of pharmacology and experimental therapeutics,
