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Whole body hyperthermia (WBH) is currently being evaluated as an adjunct to various forms of antineoplastic therapy. In this regard, the uniformity of temperature in an individual subject, induced by any given WBH system, is a significant factor. Preliminary animal investigations suggested that the bone marrow temperature may differ from core temperature during 41.8 degrees C WBH. To quantitatively evaluate this possible phenomena, dogs were utilized in conjunction with a radiant heat WBH system. It was found that mean bone marrow temperature was significantly less than core (i.e. rectal) temperature (p < 0.001), i.e. 0.27 degree C for the ilium 0.40 degree C for the humerus and 0.95 degree C for the tibia. The implications of these results to current clinical trials are discussed.
J P Woods, and
C L Schmitt, and
R C Rosenthal, and
F D'Oleire, and
H I Robins
November 1995,
Cancer letters,
J P Woods, and
C L Schmitt, and
R C Rosenthal, and
F D'Oleire, and
H I Robins
May 1993,
Journal of the National Cancer Institute,
J P Woods, and
C L Schmitt, and
R C Rosenthal, and
F D'Oleire, and
H I Robins
May 1997,
Cancer letters,
J P Woods, and
C L Schmitt, and
R C Rosenthal, and
F D'Oleire, and
H I Robins
September 1993,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
J P Woods, and
C L Schmitt, and
R C Rosenthal, and
F D'Oleire, and
H I Robins
January 1997,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
J P Woods, and
C L Schmitt, and
R C Rosenthal, and
F D'Oleire, and
H I Robins
January 1999,
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J P Woods, and
C L Schmitt, and
R C Rosenthal, and
F D'Oleire, and
H I Robins
January 1999,
Cancer chemotherapy and pharmacology,
J P Woods, and
C L Schmitt, and
R C Rosenthal, and
F D'Oleire, and
H I Robins
October 2005,
European journal of applied physiology,
J P Woods, and
C L Schmitt, and
R C Rosenthal, and
F D'Oleire, and
H I Robins
August 1985,
Cancer research,
J P Woods, and
C L Schmitt, and
R C Rosenthal, and
F D'Oleire, and
H I Robins
January 1997,
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group,
