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[Intrasubject comparison of regional cerebral blood flow between N-isopropyl-p-[123I]iodoamphetamine SPECT and 99mTc-hexamethylpropyleneamine oxime SPECT in patients with ischemic cerebrovascular disease]. 1995

Y Isaka, and T Yoshikawa, and Y Ohe, and H Nakayama, and T Abe, and K Ashida, and M Imaizumi, and S Tanaka
Department of Nuclear Medicine, Osaka National Hospital.

We compared regional cerebral blood flow (CBF) of CBF-SPECT brain imaging in two brain perfusion agents, N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) and 99mTc-hexamethylpropyleneamineoxime (99mTc-HMPAO), in the same patients with ischemic cerebrovascular disease. In eight healthy volunteers and 16 patients with chronic stage of cerebral infarction, single photon emission computed tomography (SPECT) data was normalized to the count density of the tracer in the whole brain, and then converted to the absolute units of CBF by multiplying average 133Xe-CBF in the whole-brain. One-way analysis of variance (ANOVA), grouped by the affected and contra lateral hemispheres of patients and right and left hemispheres of normal volunteers, was used to assess the changes in pattern of regional CBF (rCBF) among disease and control groups. Regional CBF was significantly reduced in patients compared with normal controls in all the brain regions on both tracers: F = 6.6-14 and p = 9.1 x 10(-4) - 1.6 x 10(-6) in IMP, and F = 5.8-14.8 and p = 2 x 10(-3) - 8.2 x 10(-7) in HMPAO. F value was higher in IMP than that of HMPAO in five of nine brain regions of interests (the frontal, temporal and occipital cortices, thalamus and the striatum), whereas F value was higher in HMPAO than IMP in the other four regions (the central lobule, parietal cortex, hippocampus and the centrum semiovale).(ABSTRACT TRUNCATED AT 250 WORDS)

UI MeSH Term Description Entries
D007457 Iodine Radioisotopes Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes. Radioisotopes, Iodine
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010091 Oximes Compounds that contain the radical R2C Aldoximes,Hydroxyimino Compounds,Ketoxime,Ketoximes,Oxime,Compounds, Hydroxyimino
D002560 Cerebrovascular Circulation The circulation of blood through the BLOOD VESSELS of the BRAIN. Brain Blood Flow,Regional Cerebral Blood Flow,Cerebral Blood Flow,Cerebral Circulation,Cerebral Perfusion Pressure,Circulation, Cerebrovascular,Blood Flow, Brain,Blood Flow, Cerebral,Brain Blood Flows,Cerebral Blood Flows,Cerebral Circulations,Cerebral Perfusion Pressures,Circulation, Cerebral,Flow, Brain Blood,Flow, Cerebral Blood,Perfusion Pressure, Cerebral,Pressure, Cerebral Perfusion
D002561 Cerebrovascular Disorders A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others. Brain Vascular Disorders,Intracranial Vascular Disorders,Vascular Diseases, Intracranial,Cerebrovascular Diseases,Cerebrovascular Insufficiency,Cerebrovascular Occlusion,Brain Vascular Disorder,Cerebrovascular Disease,Cerebrovascular Disorder,Cerebrovascular Insufficiencies,Cerebrovascular Occlusions,Disease, Cerebrovascular,Diseases, Cerebrovascular,Insufficiencies, Cerebrovascular,Insufficiency, Cerebrovascular,Intracranial Vascular Disease,Intracranial Vascular Diseases,Intracranial Vascular Disorder,Occlusion, Cerebrovascular,Occlusions, Cerebrovascular,Vascular Disease, Intracranial,Vascular Disorder, Brain,Vascular Disorder, Intracranial,Vascular Disorders, Brain,Vascular Disorders, Intracranial
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000662 Amphetamines Analogs or derivatives of AMPHETAMINE. Many are sympathomimetics and central nervous system stimulators causing excitation, vasopressin, bronchodilation, and to varying degrees, anorexia, analepsis, nasal decongestion, and some smooth muscle relaxation.
D000704 Analysis of Variance A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable. ANOVA,Analysis, Variance,Variance Analysis,Analyses, Variance,Variance Analyses
D015609 Organotechnetium Compounds Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents. Compounds, Organotechnetium

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