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OBJECTIVE To identify possible factors in the development of acute anterior uveitis (AUU) in patients with ankylosing spondylitis (AS). METHODS We investigated HLA antigens serologically, and HLA-DRB1*08 alleles by polymerase chain reaction-restriction fragment length polymorphism, in 42 Japanese AS patients with and without AAU. RESULTS Thirty-six of the AS patients (85.7%) had HLA-B27. Thirteen (65%) of the 20 patients with AAU had HLA-DR8, whereas only 1 (4.5%) of the 22 patients without AAU had DR8. The difference was statistically significant (Pcorr < 0.001). CONCLUSIONS Our data suggest that HLA-B27 is strongly associated with AS in Japanese patients and that HLA-DR8 is important for the development of AAU in Japanese patients with AS.
S M Monowarul Islam, and
J Numaga, and
Y Fujino, and
K Masuda, and
H Ohda, and
R Hirata, and
H Maeda, and
H Mitsui
October 1984,
The British journal of ophthalmology,
S M Monowarul Islam, and
J Numaga, and
Y Fujino, and
K Masuda, and
H Ohda, and
R Hirata, and
H Maeda, and
H Mitsui
February 1996,
Arthritis and rheumatism,
S M Monowarul Islam, and
J Numaga, and
Y Fujino, and
K Masuda, and
H Ohda, and
R Hirata, and
H Maeda, and
H Mitsui
January 1996,
Clinical rheumatology,
S M Monowarul Islam, and
J Numaga, and
Y Fujino, and
K Masuda, and
H Ohda, and
R Hirata, and
H Maeda, and
H Mitsui
March 1982,
Clinical genetics,
S M Monowarul Islam, and
J Numaga, and
Y Fujino, and
K Masuda, and
H Ohda, and
R Hirata, and
H Maeda, and
H Mitsui
November 1983,
British journal of rheumatology,
S M Monowarul Islam, and
J Numaga, and
Y Fujino, and
K Masuda, and
H Ohda, and
R Hirata, and
H Maeda, and
H Mitsui
January 1979,
Reumatizam,
S M Monowarul Islam, and
J Numaga, and
Y Fujino, and
K Masuda, and
H Ohda, and
R Hirata, and
H Maeda, and
H Mitsui
January 2022,
Oman journal of ophthalmology,
S M Monowarul Islam, and
J Numaga, and
Y Fujino, and
K Masuda, and
H Ohda, and
R Hirata, and
H Maeda, and
H Mitsui
January 1978,
JAMA,
S M Monowarul Islam, and
J Numaga, and
Y Fujino, and
K Masuda, and
H Ohda, and
R Hirata, and
H Maeda, and
H Mitsui
January 2023,
Molecular vision,
S M Monowarul Islam, and
J Numaga, and
Y Fujino, and
K Masuda, and
H Ohda, and
R Hirata, and
H Maeda, and
H Mitsui
February 1979,
British medical journal,
