Biomaterial Database

[Maternal effect of the mutagen-sensitive mutation mus(2)201G1 on mutagenesis in Drosophila melanogaster spermatozoid genome, induced by ethylene imine and methylmethane sulfonate]. 1995

P Ia Shvartsman, and T B Romashkina

The frequency of recessive sex-linked lethal mutations (RSLLM) induced in chromosome Muller-5 of mature sperms by treatment with ethyleneimine (EI) or methyl methanesulfonate (MMS) was shown to increase when male pronucleus or zygote was formed in the oocyte cytoplasm of the mutagen-sensitive line mus(2)201G1. The increase in the total number of mutations in the mutant cytoplasm was accompanied by a transformation of damages causing mosaic mutations into damage to the genome, which are recorded as complete mutations.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008741	Methyl Methanesulfonate	An alkylating agent in cancer therapy that may also act as a mutagen by interfering with and causing damage to DNA.	Methylmethane Sulfonate,Dimethylsulfonate,Mesilate, Methyl,Methyl Mesylate,Methyl Methylenesulfonate,Methylmesilate,Mesylate, Methyl,Methanesulfonate, Methyl,Methyl Mesilate
D009030	Mosaicism	The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from a single ZYGOTE, as opposed to CHIMERISM in which the different cell populations are derived from more than one zygote.
D009035	Mothers	Female parents, human or animal.	Mothers' Clubs,Club, Mothers',Clubs, Mothers',Mother,Mother Clubs,Mother's Clubs,Mothers Clubs,Mothers' Club
D009153	Mutagens	Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.	Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D009154	Mutation	Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.	Mutations
D004331	Drosophila melanogaster	A species of fruit fly frequently used in genetics because of the large size of its chromosomes.	D. melanogaster,Drosophila melanogasters,melanogaster, Drosophila
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001388	Aziridines	Saturated azacyclopropane compounds. They include compounds with substitutions on CARBON or NITROGEN atoms.	Ethyleneimines,Azacyclopropanes, Saturated,Dimethyleneimines,Saturated Azacyclopropanes