BIOMAT Database Logo BIOMAT Database Logo

[Interaction between mutagenic activity and chemical structure in a series of biphenyl derivatives]. 1995

I K Liubimova, and S K Abilev, and G I Migachev

A comparative study of the mutagenic activity of 21 derivatives of biphenyl was performed in the strain TA1538 of Salmonella typhimurium. The position effect of carboxyl, amide, aldehyde, and ether groups was examined. The para position of substituents, among which at least one is a nitro group, causes mutagenic activity in most of the molecules studied. Derivatives of biphenyl that have no substituents in the para position were inactive. In addition, 4-nitrobiphenyl (4-NBP), 4-nitro-2'-carboxy biphenyl (4-N-2'-C-BP), 4,4'-dinitro-2'-carboxy biphenyl (4-4'-DN-2'-C-BP), and 4,4'-dinitro-2,2'-carboxy biphenyl (4-4'-DN-2,2'-DC-BP) induced no frameshift mutations in TA1538. The most active was 2,4,4'-TN-6-C-6'-Ad-BP, giving up to 800 revertants per nmol; 2,4,6,2'-TN-4'-6'-DC-BP and 2,4,2',4'-TN-2'-C-BP, which induced 250 and 350 revertants per nmol, respectively, were highly active frameshift mutagens.

UI MeSH Term Description Entries
D009153 Mutagens Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D001713 Biphenyl Compounds Whitish aromatic crystalline organic compounds made up of two conjoined BENZENE rings. Compounds, Biphenyl
D012486 Salmonella typhimurium A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER. Salmonella typhimurium LT2
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D016368 Frameshift Mutation A type of mutation in which a number of NUCLEOTIDES deleted from or inserted into a protein coding sequence is not divisible by three, thereby causing an alteration in the READING FRAMES of the entire coding sequence downstream of the mutation. These mutations may be induced by certain types of MUTAGENS or may occur spontaneously. Mutation, Frameshift,Frame Shift Mutation,Out-of-Frame Deletion,Out-of-Frame Insertion,Out-of-Frame Mutation,Deletion, Out-of-Frame,Deletions, Out-of-Frame,Frame Shift Mutations,Frameshift Mutations,Insertion, Out-of-Frame,Insertions, Out-of-Frame,Mutation, Frame Shift,Mutation, Out-of-Frame,Mutations, Frame Shift,Mutations, Frameshift,Mutations, Out-of-Frame,Out of Frame Deletion,Out of Frame Insertion,Out of Frame Mutation,Out-of-Frame Deletions,Out-of-Frame Insertions,Out-of-Frame Mutations

Related Publications

I K Liubimova, and S K Abilev, and G I Migachev
[Relation between the chemical structure and mutagenic activity of derivatives of the herbicide toluin].
November 1985, Genetika,
I K Liubimova, and S K Abilev, and G I Migachev
Structure, chemical reactivity, and in vitro mutagenic activity in a series of fecapentaene analogues.
March 1990, Mutation research,
I K Liubimova, and S K Abilev, and G I Migachev
Relationships between the chemical structure and pharmacological activity in a series of synthetic quinuclidine derivatives.
January 1969, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques,
I K Liubimova, and S K Abilev, and G I Migachev
Quantitative relationship between structure and mutagenic activity in a series of 5-nitroimidazoles.
January 1983, Teratogenesis, carcinogenesis, and mutagenesis,
I K Liubimova, and S K Abilev, and G I Migachev
Relationship between chemical structure and pharmacological activity in a series of central muscle relaxant oxadiazole derivatives.
January 1970, Acta physiologica Academiae Scientiarum Hungaricae,
I K Liubimova, and S K Abilev, and G I Migachev
Relationship between chemical structure and pharmacological activity in a series of 5-alkoxy substitution derivatives of tryptamine.
January 1965, Federation proceedings. Translation supplement; selected translations from medical-related science,
I K Liubimova, and S K Abilev, and G I Migachev
[Relationship between chemical structure and antiedematous effect in a series of derivatives of pyrazolone].
January 1968, Farmakologiia i toksikologiia,
I K Liubimova, and S K Abilev, and G I Migachev
The relationship between the chemical structure and hypotensive activity of a series of new benzimidazole and quinoxaline derivatives.
January 1973, Farmakologiia i toksikologiia,
I K Liubimova, and S K Abilev, and G I Migachev
[On interrelations between chemical structure and pharmacological action in a series of phenylenediamine derivatives].
January 1962, Farmakologiia i toksikologiia,
I K Liubimova, and S K Abilev, and G I Migachev
ERbeta ligands. Part 2: Synthesis and structure-activity relationships of a series of 4-hydroxy-biphenyl-carbaldehyde oxime derivatives.
May 2004, Bioorganic & medicinal chemistry,
Copied contents to your clipboard!