-transparent.png){kind=logo}
Jumping translocations are an unusual phenomenon and have been rarely reported in leukemia. We report three patients whose leukemic cells had multiple related clones resulting from unbalanced jumping translocations of 1q and 7q to chromosomes 1, 8, 15, 21 and 22. The chromosome findings, together with limited published reports, suggest that jumping translocations are new non-random rearrangements and may represent poor prognostic biological markers. Although their origin is unknown, circumstantial evidence suggests that telomeric ends of receptor chromosomes may play a role in stabilizing jumping translocations in dividing malignant cells.
Related Publications
V Najfeld, and
B Hauschildt, and
A Scalise, and
A Gattani, and
R Patel, and
E P Ambinder, and
L R Silverman
March 1995,
Cancer genetics and cytogenetics,
V Najfeld, and
B Hauschildt, and
A Scalise, and
A Gattani, and
R Patel, and
E P Ambinder, and
L R Silverman
January 1999,
Cancer genetics and cytogenetics,
V Najfeld, and
B Hauschildt, and
A Scalise, and
A Gattani, and
R Patel, and
E P Ambinder, and
L R Silverman
August 2007,
Genes, chromosomes & cancer,
V Najfeld, and
B Hauschildt, and
A Scalise, and
A Gattani, and
R Patel, and
E P Ambinder, and
L R Silverman
November 1993,
Cancer genetics and cytogenetics,
V Najfeld, and
B Hauschildt, and
A Scalise, and
A Gattani, and
R Patel, and
E P Ambinder, and
L R Silverman
September 2005,
Cancer genetics and cytogenetics,
V Najfeld, and
B Hauschildt, and
A Scalise, and
A Gattani, and
R Patel, and
E P Ambinder, and
L R Silverman
September 2016,
Cancer genetics,
V Najfeld, and
B Hauschildt, and
A Scalise, and
A Gattani, and
R Patel, and
E P Ambinder, and
L R Silverman
January 2000,
Cytogenetics and cell genetics,
V Najfeld, and
B Hauschildt, and
A Scalise, and
A Gattani, and
R Patel, and
E P Ambinder, and
L R Silverman
February 1991,
Cancer genetics and cytogenetics,
V Najfeld, and
B Hauschildt, and
A Scalise, and
A Gattani, and
R Patel, and
E P Ambinder, and
L R Silverman
April 2000,
Cancer genetics and cytogenetics,
V Najfeld, and
B Hauschildt, and
A Scalise, and
A Gattani, and
R Patel, and
E P Ambinder, and
L R Silverman
April 2014,
Blood,
