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22 patients infected with fluoroquinolone-resistant Mycobacterium tuberculosis in New York City were identified between January, 1991, and November, 1993. In 16 patients resistance arose as a result of inadequate or inappropriate treatment. 6 patients had primary infection with fluoroquinolone-resistant organisms; 5 acquired the organisms nosocomially. Seven distinct patterns of restriction-fragment length polymorphism were identified in isolates from 21 patients. Fluoroquinolones should be restricted to patients with multidrug-resistant disease or intolerance to other antituberculosis drugs. All patients with multidrug-resistant tuberculosis should be on directly observed therapy.
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V Kapur, and
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The New England journal of medicine,
E A Sullivan, and
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L Palumbo, and
V Kapur, and
J M Musser, and
A Ebrahimzadeh, and
T R Frieden
July 1993,
Lancet (London, England),
E A Sullivan, and
B N Kreiswirth, and
L Palumbo, and
V Kapur, and
J M Musser, and
A Ebrahimzadeh, and
T R Frieden
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The New England journal of medicine,
E A Sullivan, and
B N Kreiswirth, and
L Palumbo, and
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The New England journal of medicine,
E A Sullivan, and
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J M Musser, and
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The New England journal of medicine,
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
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July 1990,
New York state journal of medicine,
E A Sullivan, and
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January 1999,
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease,
E A Sullivan, and
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October 2015,
Antimicrobial agents and chemotherapy,
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The virtual mentor : VM,
