-transparent.png){kind=logo}
As zymosan-induced arthritis in rats combines dual activation of early prostaglandin-dependent processes (edema, fever, pain) and IL-1 related effects on cartilage metabolism, we compared the respective influences of indomethacin (IMT) and dexamethasone (DEX) on its course. Different parameters were assessed: knee swelling, febrile response, loss of activity, cartilage metabolism and histology. DEX improved all these parameters, while IMT exerted only light beneficial effects on fever and knee swelling without obvious beneficial influence on cartilage metabolism and histological lesions. These results suggest that anti-inflammatory activities of DEX and IMT are due to interferences with different pathways during zymosan-induced arthritis in rats.
P Gegout, and
P Gillet, and
B Terlain, and
P Netter
July 1987,
Annals of the rheumatic diseases,
P Gegout, and
P Gillet, and
B Terlain, and
P Netter
March 1982,
Clinical and experimental immunology,
P Gegout, and
P Gillet, and
B Terlain, and
P Netter
September 2011,
International immunopharmacology,
P Gegout, and
P Gillet, and
B Terlain, and
P Netter
December 2018,
Pharmaceutical biology,
P Gegout, and
P Gillet, and
B Terlain, and
P Netter
January 1982,
Voprosy revmatizma,
P Gegout, and
P Gillet, and
B Terlain, and
P Netter
November 2015,
Journal of ethnopharmacology,
P Gegout, and
P Gillet, and
B Terlain, and
P Netter
January 2020,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
P Gegout, and
P Gillet, and
B Terlain, and
P Netter
July 1991,
Agents and actions,
P Gegout, and
P Gillet, and
B Terlain, and
P Netter
April 2022,
Cell biochemistry and function,
P Gegout, and
P Gillet, and
B Terlain, and
P Netter
July 2016,
Journal of ethnopharmacology,
