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The in vitro effect of melatonin on the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from fetal rat pituitary cells was investigated. A significant inhibition of LH release induced by 10(-9) M luteinizing hormone releasing hormone (LHRH) was seen when cells were incubated with 10(-9) M melatonin. FSH release was unaffected by either LHRH alone or LHRH in combination with melatonin. In addition, the significant inhibitory effect of melatonin was reduced by pretreatment of the pituitary cells with 10(-10) M melatonin. These findings indicate that melatonin can act directly on the fetal pituitary gland to suppress LHRH-induced release of LH perhaps by a mechanism which eventually involves down-regulation of the melatonin receptors.
A Hattori, and
D C Herbert, and
M K Vaughan, and
K Yaga, and
R J Reiter
May 1978,
Biology of reproduction,
A Hattori, and
D C Herbert, and
M K Vaughan, and
K Yaga, and
R J Reiter
November 1997,
Endocrinology,
A Hattori, and
D C Herbert, and
M K Vaughan, and
K Yaga, and
R J Reiter
March 1983,
Endocrinology,
A Hattori, and
D C Herbert, and
M K Vaughan, and
K Yaga, and
R J Reiter
June 1985,
Endocrinology,
A Hattori, and
D C Herbert, and
M K Vaughan, and
K Yaga, and
R J Reiter
August 1977,
Endocrinology,
A Hattori, and
D C Herbert, and
M K Vaughan, and
K Yaga, and
R J Reiter
June 1994,
Biology of reproduction,
A Hattori, and
D C Herbert, and
M K Vaughan, and
K Yaga, and
R J Reiter
March 1980,
Life sciences,
A Hattori, and
D C Herbert, and
M K Vaughan, and
K Yaga, and
R J Reiter
January 2001,
Vitamins and hormones,
A Hattori, and
D C Herbert, and
M K Vaughan, and
K Yaga, and
R J Reiter
February 1987,
Endocrinology,
A Hattori, and
D C Herbert, and
M K Vaughan, and
K Yaga, and
R J Reiter
February 1983,
Canadian journal of physiology and pharmacology,
