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The ability of adenosine agonists to modulate the electrically evoked release of acetylcholine (ACh) from [3H]choline preloaded guinea-pig superior cervical ganglia (SCG) was investigated. The adenosine A1-receptor selective agonist N6-cyclohexyladenosine (CHA) and 2-chloroadenosine (2-CADO) inhibited the evoked transmitter release, the effect being reversed by the A1-receptor selective antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), and by sulmazole (SUL), which blocks both the A1-receptor and the adenylate cyclase inhibitory regulator Gi. In whole ganglia, CHA decreased both the basal and the forskolin (FSK)-stimulated cyclic AMP synthesis. The latter effect was again prevented by the A1 antagonist DPCPX. These results are compatible with the existence, in the guinea-pig SCG, of adenosine A1-receptors, part of which are located on the presynaptic nerve terminals mediating an inhibition of ACh release.
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B Pavan, and
E Fabbri, and
F Ginanni-Corradini, and
D Arcelli, and
A Poli
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F Ginanni-Corradini, and
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A Poli
December 1983,
Neuroscience letters,
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F Ginanni-Corradini, and
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A Poli
January 1971,
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January 1980,
Brain research,
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October 1986,
Neurochemical research,
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The Journal of physiology,
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September 1989,
Neuroscience letters,
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Neurochemical research,
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December 1963,
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