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Type 1 diabetes mellitus is caused by severe insulin deficiency secondary to the autoimmune destruction of pancreatic beta cells. Patients need to be controlled by periodic insulin injections to prevent the development of ketoacidosis, which can be fatal. Sustained, low-level expression of the rat insulin 1 gene from the liver of severely diabetic rats was achieved by in vivo administration of a recombinant retroviral vector. Ketoacidosis was prevented and the treated animals exhibited normoglycemia during a 24-hr fast, with no evidence of hypoglycemia. Histopathological examination of the liver in the treated animals showed no apparent abnormalities. Thus, the liver is an excellent target organ for ectopic expression of the insulin gene as a potential treatment modality for type 1 diabetes mellitus by gene therapy.
T M Kolodka, and
M Finegold, and
L Moss, and
S L Woo
June 1997,
Molecular endocrinology (Baltimore, Md.),
T M Kolodka, and
M Finegold, and
L Moss, and
S L Woo
October 2003,
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
T M Kolodka, and
M Finegold, and
L Moss, and
S L Woo
March 2006,
Diabetes research and clinical practice,
T M Kolodka, and
M Finegold, and
L Moss, and
S L Woo
May 2012,
Molecular therapy : the journal of the American Society of Gene Therapy,
T M Kolodka, and
M Finegold, and
L Moss, and
S L Woo
April 2008,
Diabetologia,
T M Kolodka, and
M Finegold, and
L Moss, and
S L Woo
April 2015,
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation,
T M Kolodka, and
M Finegold, and
L Moss, and
S L Woo
July 2008,
World journal of gastroenterology,
T M Kolodka, and
M Finegold, and
L Moss, and
S L Woo
December 1998,
Diabetologia,
T M Kolodka, and
M Finegold, and
L Moss, and
S L Woo
September 2007,
Diabetologia,
T M Kolodka, and
M Finegold, and
L Moss, and
S L Woo
June 2008,
Pharmaceutical research,
