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Using an HPLC procedure, we evaluated > 10 minor hemoglobins (Hbs) in healthy adults, individuals on long-term aspirin therapy, diabetic subjects, and uremic patients. Hb A1c and Hb A1d3 were the most abundant and important minor Hb components, respectively, accounting for 4.10% +/- 0.50% and 3.46% +/- 0.43% of total Hb in 361 healthy subjects. Acetylated Hb A was a potential interferent in the measurement of Hb A1c. The amounts of both Hb A1d3 and Hb A1carb were significantly increased in uremic patients, indicating that these Hb adducts may be carbamylated. There was a significant correlation (r = 0.69, P < 0.0001) between the amounts of Hb A1d3 and plasma urea in uremic patients. Nonuremic subjects were clearly separated from uremic patients with regard to the Hb A1d3 content of their total Hb. Our data suggest that Hb A1d3 is useful for assessment of the uremic state and that the combination of Hb A1c and Hb A1d3 could be well-suited for simultaneous control of carbohydrate and urea metabolism.
E Bissé, and
P Huaman-Guillen, and
H Wieland
May 1984,
American journal of obstetrics and gynecology,
E Bissé, and
P Huaman-Guillen, and
H Wieland
November 1984,
American journal of obstetrics and gynecology,
E Bissé, and
P Huaman-Guillen, and
H Wieland
August 1983,
The Journal of laboratory and clinical medicine,
E Bissé, and
P Huaman-Guillen, and
H Wieland
December 1989,
Nihon rinsho. Japanese journal of clinical medicine,
E Bissé, and
P Huaman-Guillen, and
H Wieland
May 2009,
Journal of diabetes science and technology,
E Bissé, and
P Huaman-Guillen, and
H Wieland
July 2001,
Klinicheskaia laboratornaia diagnostika,
E Bissé, and
P Huaman-Guillen, and
H Wieland
August 2009,
Clinica chimica acta; international journal of clinical chemistry,
E Bissé, and
P Huaman-Guillen, and
H Wieland
February 1985,
Clinical biochemistry,
E Bissé, and
P Huaman-Guillen, and
H Wieland
February 1981,
Clinical biochemistry,
E Bissé, and
P Huaman-Guillen, and
H Wieland
May 2016,
Orvosi hetilap,
