Biomaterial Database

A2 adenosine receptors in human glomerular mesangial cells. 1995

V Stefanović, and P Vlahović

Institute of Nephrology and Hemodialysis, Faculty of Medicine, Nis, Yugoslavia.

A2 adenosine receptors were characterized in human glomerular mesangial cells using [3H]5'-N-ethylcarboxamidoadenosine (NECA) as a tracer. There was a single group of receptor sites with a KD of 184 nM, and a number of sites of 317 fmol/mg of cell protein. Adenosine agonists increased 5'-nucleotidase activity via A2 receptor stimulation. The specific A2 agonist-NECA, at 0.1 and 1 micron, was a potent inhibitor of DNA synthesis.

UI	MeSH Term	Description	Entries
D005920	Glomerular Mesangium	The thin membranous structure supporting the adjoining glomerular capillaries. It is composed of GLOMERULAR MESANGIAL CELLS and their EXTRACELLULAR MATRIX.	Mesangium, Glomerular,Mesangial Extracellular Matrix,Extracellular Matrices, Mesangial,Extracellular Matrix, Mesangial,Glomerular Mesangiums,Matrices, Mesangial Extracellular,Matrix, Mesangial Extracellular,Mesangial Extracellular Matrices,Mesangiums, Glomerular
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000241	Adenosine	A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.	Adenocard,Adenoscan
D014316	Tritium	The radioactive isotope of hydrogen also known as hydrogen-3. It contains two NEUTRONS and one PROTON in its nucleus and decays to produce low energy BETA PARTICLES.	Hydrogen-3,Hydrogen 3
D015720	5'-Nucleotidase	A glycoprotein enzyme present in various organs and in many cells. The enzyme catalyzes the hydrolysis of a 5'-ribonucleotide to a ribonucleoside and orthophosphate in the presence of water. It is cation-dependent and exists in a membrane-bound and soluble form. EC 3.1.3.5.	5'-AMP Nucleotidase,AMP Phosphatase,Adenylate Phosphatase,Antigens, CD73,CD73 Antigens,Cytidylate Phosphatase,Ecto-5'-Nucleotidase,IMP Nucleotidase,IMP Phosphatase,Inosinate Phosphatase,Pyrimidine 5'-Nucleotidase,Thymidine Phosphatase,Uridylate 5'-Nucleotidase,5'-Nucleotidase Phosphoribolase,Antigen, CD73,IMPase,5' AMP Nucleotidase,5' Nucleotidase,5' Nucleotidase Phosphoribolase,CD73 Antigen,Ecto 5' Nucleotidase,Pyrimidine 5' Nucleotidase,Uridylate 5' Nucleotidase
D015762	2-Chloroadenosine	2-Chloroadenosine. A metabolically stable analog of adenosine which acts as an adenosine receptor agonist. The compound has a potent effect on the peripheral and central nervous system.	2 Chloroadenosine
D018047	Receptors, Purinergic P1	A class of cell surface receptors that prefer ADENOSINE to other endogenous PURINES. Purinergic P1 receptors are widespread in the body including the cardiovascular, respiratory, immune, and nervous systems. There are at least two pharmacologically distinguishable types (A1 and A2, or Ri and Ra).	Adenosine Receptors,P1 Purinoceptors,Purinergic P1 Receptors,Receptors, Adenosine,Adenosine Receptor,P1 Purinoceptor,Receptor, Purinergic P1,P1 Receptor, Purinergic,P1 Receptors, Purinergic,Purinergic P1 Receptor,Purinoceptor, P1,Purinoceptors, P1,Receptor, Adenosine
D019830	Adenosine-5'-(N-ethylcarboxamide)	A stable adenosine A1 and A2 receptor agonist. Experimentally, it inhibits cAMP and cGMP phosphodiesterase activity.	5'-N-Ethylcarboxamidoadenosine,N-Ethylcarboxamidoadenosine,NECA,Adenosine-5'-N-ethyluronamide,N6-Ethyl-carboxamido Adenosine,5' N Ethylcarboxamidoadenosine,Adenosine 5' N ethyluronamide,Adenosine, N6-Ethyl-carboxamido,N Ethylcarboxamidoadenosine,N6 Ethyl carboxamido Adenosine

Related Publications

V Stefanović, and P Vlahović

Adenosine inhibits PDGF-induced growth of human glomerular mesangial cells via A(2B) receptors.

September 2005, Hypertension (Dallas, Tex. : 1979),

V Stefanović, and P Vlahović

Adenosine stimulates 5'-nucleotidase activity in rat mesangial cells via A2 receptors.

September 1993, FEBS letters,

V Stefanović, and P Vlahović

Adenosine-induced apoptosis in glomerular mesangial cells.

April 2002, Kidney international,

V Stefanović, and P Vlahović

Thromboxane A2 modulates the fibrinolytic system in glomerular mesangial cells.

August 1998, The American journal of physiology,

V Stefanović, and P Vlahović

Functional endothelin 1 receptors on human glomerular podocytes and mesangial cells.

January 1992, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,

V Stefanović, and P Vlahović

Human retinal pigment epithelial cells in culture possess A2-adenosine receptors.

July 1989, Brain research,

V Stefanović, and P Vlahović

Characterization of atrial natriuretic factor receptors in human glomerular epithelial and mesangial cells.

October 1990, The American journal of physiology,

V Stefanović, and P Vlahović

Cytokine regulation of group II phospholipase A2 expression in glomerular mesangial cells.

January 1993, European journal of clinical pharmacology,

V Stefanović, and P Vlahović

Human glomerular smooth muscle (mesangial) cells in culture.

February 1976, Laboratory investigation; a journal of technical methods and pathology,