Biomaterial Database

[Quantitative changes of hepatic microcirculation and mitochondrial function after splenectomy in liver cirrhosis rats]. 1995

E Meguro

Department of Biochemistry, Iwate Medical University School of Medicine, Morioka, Japan.

To evaluate the potential risk of splenectomy for patients with cirrhotic liver. I measured quantitative time-course changes of portal pressure (PP), and hepatic tissue blood flow (TBF) by hydrogen clearance method and adenine nucleotides by HPLC in a rat model. Intraperitoneal thioacetamide injection (200mg/kg x 30) produced histologically proven cirrhotic liver (TAAs) as well as increasing the spleen weight and PP compared to controls. PP and TBF simultaneously decreased on the 1st postoperative day (POD) after splenectomy in TAAs, whereas controls showed no changes in these parameter after splenectomy. Although PP of TAAs remained decreased until the 7th POD after splenectomy, their TBF gradually increased between the 2nd and 7th PODs returning to the baseline value. Recovery of ATP or energy charge after their decrease on the 1st POD was delayed in TAAs. Splenectomy in TAAs enhanced the deterioration of energical metabolism. Splenectomy in cirrhotic rats resulted in an additional postoperative risk.

UI	MeSH Term	Description	Entries
D008102	Liver Circulation	The circulation of BLOOD through the LIVER.	Hepatic Circulation,Circulation, Liver,Circulation, Hepatic
D008106	Liver Cirrhosis, Experimental	Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.	Hepatic Cirrhosis, Experimental,Cirrhoses, Experimental Liver,Cirrhosis, Experimental Liver,Experimental Liver Cirrhoses,Experimental Liver Cirrhosis,Liver Cirrhoses, Experimental,Experimental Hepatic Cirrhosis
D008297	Male		Males
D008833	Microcirculation	The circulation of the BLOOD through the MICROVASCULAR NETWORK.	Microvascular Blood Flow,Microvascular Circulation,Blood Flow, Microvascular,Circulation, Microvascular,Flow, Microvascular Blood,Microvascular Blood Flows,Microvascular Circulations
D008930	Mitochondria, Liver	Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4)	Liver Mitochondria,Liver Mitochondrion,Mitochondrion, Liver
D004734	Energy Metabolism	The chemical reactions involved in the production and utilization of various forms of energy in cells.	Bioenergetics,Energy Expenditure,Bioenergetic,Energy Expenditures,Energy Metabolisms,Expenditure, Energy,Expenditures, Energy,Metabolism, Energy,Metabolisms, Energy
D000255	Adenosine Triphosphate	An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.	ATP,Adenosine Triphosphate, Calcium Salt,Adenosine Triphosphate, Chromium Salt,Adenosine Triphosphate, Magnesium Salt,Adenosine Triphosphate, Manganese Salt,Adenylpyrophosphate,CaATP,CrATP,Manganese Adenosine Triphosphate,MgATP,MnATP,ATP-MgCl2,Adenosine Triphosphate, Chromium Ammonium Salt,Adenosine Triphosphate, Magnesium Chloride,Atriphos,Chromium Adenosine Triphosphate,Cr(H2O)4 ATP,Magnesium Adenosine Triphosphate,Striadyne,ATP MgCl2
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013156	Splenectomy	Surgical procedure involving either partial or entire removal of the spleen.	Splenectomies
D017082	Portal Pressure	The venous pressure measured in the PORTAL VEIN.	Portal Venous Pressure,Pressure, Portal,Pressure, Portal Venous,Venous Pressure, Portal