-transparent.png){kind=logo}
Children with juvenile rheumatoid arthritis (JRA) often exhibit delayed skeletal development. Previous evaluations of growth hormone (hGH) levels in these children have used single-value blood determinations. We sought to extend information on possible hGH deficiency in children with short stature and JRA by measuring 24-hour hGH pulsatile secretion. Five children with JRA were identified as having a height less than the 3rd percentile, and one child with a height at the 25th percentile. Three of these had abnormally low 24-hour serum hGH secretion. Two underwent a 24-month trial of human recombinant hGH; both exhibited only marginally accelerated growth. These results suggest that children with JRA and persistent short stature may have low hGH secretion without an adequate physiologic response to exogenous hGH administration.
R J Hopp, and
J Degan, and
K Corley, and
C B Lindsley, and
J T Cassidy
January 1994,
Hormone research,
R J Hopp, and
J Degan, and
K Corley, and
C B Lindsley, and
J T Cassidy
February 1999,
Acta paediatrica (Oslo, Norway : 1992). Supplement,
R J Hopp, and
J Degan, and
K Corley, and
C B Lindsley, and
J T Cassidy
May 1992,
The Journal of pediatrics,
R J Hopp, and
J Degan, and
K Corley, and
C B Lindsley, and
J T Cassidy
January 1988,
Hormone research,
R J Hopp, and
J Degan, and
K Corley, and
C B Lindsley, and
J T Cassidy
October 1994,
Trends in endocrinology and metabolism: TEM,
R J Hopp, and
J Degan, and
K Corley, and
C B Lindsley, and
J T Cassidy
February 1994,
The Journal of clinical endocrinology and metabolism,
R J Hopp, and
J Degan, and
K Corley, and
C B Lindsley, and
J T Cassidy
March 2011,
BMJ (Clinical research ed.),
R J Hopp, and
J Degan, and
K Corley, and
C B Lindsley, and
J T Cassidy
January 1989,
Acta paediatrica Scandinavica. Supplement,
R J Hopp, and
J Degan, and
K Corley, and
C B Lindsley, and
J T Cassidy
January 2000,
Hormone research,
R J Hopp, and
J Degan, and
K Corley, and
C B Lindsley, and
J T Cassidy
January 1987,
Pediatrician,
