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An analysis of the gonadotrophin response to an intravenous injection of LH-RH (50 mug) has been undertaken in 41 patients with secondary amenorrhoea. Thirty-five of the patients were free of any recognizable pathology to account for their amenorrhoea and apparently had a dysfunction of the hypothalamic-pituitary axis. In these patients, the gonadotrophin response to LH-RH was highly variable. There was in general a correlation between baseline plasma LH or FSH levels and their respective increments. There was no correlation, however, between basal oestrogen levels and gonadotrophin increments except in the case of those patients whose basal levels of plasma FSH were higher than those of LH and in those patients whose body weight was less than the ideal for the population. It appears that the gonadotrophin response to a single injection of LH-RH in the majority of patients with secondary amenorrhoea of unknown origin is too variable to be of use either as a diagnostic or prognostic tool.
S R Henderson, and
J Bonnar, and
A R Souka, and
W Bogie, and
P MacKinnon, and
J Mattock, and
A Dutton
October 1972,
The Journal of obstetrics and gynaecology of the British Commonwealth,
S R Henderson, and
J Bonnar, and
A R Souka, and
W Bogie, and
P MacKinnon, and
J Mattock, and
A Dutton
April 1975,
British journal of obstetrics and gynaecology,
S R Henderson, and
J Bonnar, and
A R Souka, and
W Bogie, and
P MacKinnon, and
J Mattock, and
A Dutton
November 1975,
Chemical & pharmaceutical bulletin,
S R Henderson, and
J Bonnar, and
A R Souka, and
W Bogie, and
P MacKinnon, and
J Mattock, and
A Dutton
November 1973,
Berliner und Munchener tierarztliche Wochenschrift,
S R Henderson, and
J Bonnar, and
A R Souka, and
W Bogie, and
P MacKinnon, and
J Mattock, and
A Dutton
September 1984,
General and comparative endocrinology,
S R Henderson, and
J Bonnar, and
A R Souka, and
W Bogie, and
P MacKinnon, and
J Mattock, and
A Dutton
January 1974,
Annales d'endocrinologie,
S R Henderson, and
J Bonnar, and
A R Souka, and
W Bogie, and
P MacKinnon, and
J Mattock, and
A Dutton
July 1973,
Journal of animal science,
S R Henderson, and
J Bonnar, and
A R Souka, and
W Bogie, and
P MacKinnon, and
J Mattock, and
A Dutton
June 1983,
Journal of pediatric surgery,
S R Henderson, and
J Bonnar, and
A R Souka, and
W Bogie, and
P MacKinnon, and
J Mattock, and
A Dutton
September 1973,
Journal of medicinal chemistry,
S R Henderson, and
J Bonnar, and
A R Souka, and
W Bogie, and
P MacKinnon, and
J Mattock, and
A Dutton
August 1973,
The Journal of clinical endocrinology and metabolism,
