Biomaterial Database

Insulin-like growth factor-I in children with short stature. 1994

W Y Tsai, and J S Lee

Department of Pediatrics, National Taiwan University Hospital, Taipei, R.O.C.

The purpose of this study was to evaluate the clinical application of serum insulin-like growth factor-I (IGF-I) levels for the workup of prepubertal children with short stature. IGF-I serum levels were measured by radioimmunoassay in 92 short prepubertal children (55 normal-short children, 18 dysmorphic-short children, and 19 children with classical growth hormone deficiency) and 105 normal prepubertal children. The serum IGF-I levels (mean +/- SEM) in these three groups of short children were 160 +/- 9 ng/ml, 188 +/- 16 ng/ml and 26 +/- 3 ng/ml, respectively. The mean serum IGF-I level for the 105 normal prepubertal children was 160 +/- 7 ng/ml. The mean serum IGF-I levels of the first two groups of short children were not significantly different from that of the prepubertal children with normal stature. On the other hand, the mean serum IGF-I level in children with classical growth hormone deficiency was significantly lower than those of the other two groups of short children and that of prepubertal children with normal stature. Our study shows that the determination of serum IGF-I levels is of clinical value in the evaluation of short prepubertal children.

UI	MeSH Term	Description	Entries
D007334	Insulin-Like Growth Factor I	A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor.	IGF-I,Somatomedin C,IGF-1,IGF-I-SmC,Insulin Like Growth Factor I,Insulin-Like Somatomedin Peptide I,Insulin Like Somatomedin Peptide I
D008297	Male		Males
D012016	Reference Values	The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.	Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D002681	China	A country spanning from central Asia to the Pacific Ocean.	Inner Mongolia,Manchuria,People's Republic of China,Sinkiang,Mainland China
D005260	Female		Females
D006130	Growth Disorders	Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth.	Stunted Growth,Stunting,Disorder, Growth,Growth Disorder,Growth, Stunted,Stuntings
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths