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Bone marrow and spleen from Rauscher leukemia virus (RLV) infected BALB/c mice were tested for proliferative activity at various time intervals after infection using the spleen colony assay. Both bone marrow and spleen derived colonies showed a modified maturation behavior. The erythroid colonies were classified into three consecutive stages of maturation according to morphologic criteria. Both bone marrow and spleen derived erythroid colonies exhibited a retardation of maturation upon RLV infection of the donor mice; the spleen derived erythroid colonies showed the most severe changes. RLV itself could not mimic this phenomenon; moreover it was shown by immunofluorescence that only low amounts of RLV were present in the spleen colonies. It is therefore suggested that RLV modifies part of the stem cell compartment leading to a prolonged cycle time of proerythroblasts and hence to a retardation of colony growth.
H J Van Beek, and
E Van Hull, and
L J Van Griensven
December 1973,
Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology,
H J Van Beek, and
E Van Hull, and
L J Van Griensven
November 1975,
Journal of the National Cancer Institute,
H J Van Beek, and
E Van Hull, and
L J Van Griensven
December 1974,
European journal of cancer,
H J Van Beek, and
E Van Hull, and
L J Van Griensven
June 1966,
Journal of the National Cancer Institute,
H J Van Beek, and
E Van Hull, and
L J Van Griensven
January 1979,
Leukemia research,
H J Van Beek, and
E Van Hull, and
L J Van Griensven
January 1980,
Archivum immunologiae et therapiae experimentalis,
H J Van Beek, and
E Van Hull, and
L J Van Griensven
January 1968,
Bibliotheca haematologica,
H J Van Beek, and
E Van Hull, and
L J Van Griensven
April 1972,
Biochemical and biophysical research communications,
H J Van Beek, and
E Van Hull, and
L J Van Griensven
January 1973,
Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology,
H J Van Beek, and
E Van Hull, and
L J Van Griensven
January 1988,
Advances in experimental medicine and biology,
